SLCO1B1 polymorphism is not associated with risk of statin-induced myalgia/myopathy in a Czech population
Jazyk angličtina Země Spojené státy americké Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25992810
PubMed Central
PMC4450600
DOI
10.12659/msm.893007
PII: 893007
Knihovny.cz E-zdroje
- MeSH
- atorvastatin aplikace a dávkování škodlivé účinky farmakokinetika terapeutické užití MeSH
- diabetes mellitus epidemiologie MeSH
- dyslipidemie farmakoterapie genetika MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci MeSH
- genotyp MeSH
- hepatocyty metabolismus MeSH
- jednonukleotidový polymorfismus * MeSH
- kouření epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- modely genetické MeSH
- myalgie chemicky indukované epidemiologie genetika MeSH
- nemoci svalů chemicky indukované epidemiologie genetika MeSH
- obezita epidemiologie MeSH
- polypeptid C přenášející organické anionty MeSH
- přenašeče organických aniontů genetika fyziologie MeSH
- senioři MeSH
- simvastatin aplikace a dávkování škodlivé účinky farmakokinetika terapeutické užití MeSH
- statiny aplikace a dávkování škodlivé účinky farmakokinetika terapeutické užití MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- atorvastatin MeSH
- polypeptid C přenášející organické anionty MeSH
- přenašeče organických aniontů MeSH
- simvastatin MeSH
- SLCO1B1 protein, human MeSH Prohlížeč
- statiny MeSH
BACKGROUND: Gene SLCO1B1, encoding solute organic anionic transport polypeptide OATP1B1, belongs to the group of candidates potentially influencing statin treatment safety. OATP1B1 regulates (not only) the hepatic uptake of statins. Its genetic variation was described as an important predictor of statin-associated myopathy in a cohort of patients treated with a maximum dose of simvastatin. However, the impact of SLCO1B1 gene polymorphism on this risk in patients treated with other statins or lower doses of simvastatin needs to be assessed. Therefore, we performed the present study. MATERIAL/METHODS: SLCO1B1 tagging rs4363657 polymorphism was analyzed in 2 groups of patients with dyslipidemia (treated with simvastatin or atorvastatin, 10 or 20 mg per day), subgroup with statin-induced myalgia (N=286), and subgroup (N=707) without myalgia/myopathy, and in 2301 population controls without lipid-lowering treatment. RESULTS: Frequency of the individual genotypes in patients with myalgia/myopathy (TT=62.3%, CT=34.5%, CC=2.8%) did not significantly differ (both P values over 0.19) from that in patients without muscle symptoms (TT=61.4%, CT=32.9%, CC=5.7%) or from the population controls (TT=63.9%, CT=32.5%, CC=3.6%). Null results were also obtained for the dominant and recessive models of the analysis. CONCLUSIONS: In Czech patients treated with low statin doses, there is no association between SLCO1B1 gene polymorphism and risk of myalgia/myopathy.
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