Bioptic Study of Left and Right Atrial Interstitium in Cardiac Patients with and without Atrial Fibrillation: Interatrial but Not Rhythm-Based Differences
Jazyk angličtina Země Spojené státy americké Médium electronic-ecollection
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26067062
PubMed Central
PMC4466374
DOI
10.1371/journal.pone.0129124
PII: PONE-D-15-08410
Knihovny.cz E-zdroje
- MeSH
- elastin genetika metabolismus MeSH
- extracelulární matrix genetika metabolismus MeSH
- fibrilace síní metabolismus patologie patofyziologie MeSH
- kolagen typ III genetika metabolismus MeSH
- kolagen typu I genetika metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- orgánová specificita MeSH
- senioři MeSH
- srdce - funkce síní MeSH
- srdeční frekvence * MeSH
- srdeční síně metabolismus patologie MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- elastin MeSH
- kolagen typ III MeSH
- kolagen typu I MeSH
One of the generally recognized factors contributing to the initiation and maintenance of atrial fibrillation (AF) is structural remodeling of the myocardium that affects both atrial cardiomyocytes as well as interstitium. The goal of this study was to characterize morphologically and functionally interstitium of atria in patients with AF or in sinus rhythm (SR) who were indicated to heart surgery. Patient population consisted of 46 subjects (19 with long-term persistent AF, and 27 in SR) undergoing coronary bypass or valve surgery. Peroperative bioptic samples of the left and the right atria were examined using immunohistochemistry to visualize and quantify collagen I, collagen III, elastin, desmin, smooth muscle actin, endothelium and Vascular Endothelial Growth Factor (VEGF). The content of interstitial elastin, collagen I, and collagen III in atrial tissue was similar in AF and SR groups. However, the right atrium was more than twofold more abundant in elastin as compared with the left atrium and similar difference was found for collagen I and III. The right atrium showed also higher VEGF expression and lower microvascular density as compared to the left atrium. No significant changes in atrial extracellular matrix fiber content, microvascular density and angiogenic signaling, attributable to AF, were found in this cohort of patients with structural heart disease. This finding suggests that interstitial fibrosis and other morphological changes in atrial tissue are rather linked to structural heart disease than to AF per se. Significant regional differences in interstitial structure between right and left atrium is a novel observation that deserves further investigation.
Institute for Clinical and Experimental Medicine IKEM Department of Cardiology Prague Czech Republic
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"Form follows function": the developmental morphology of the cardiac atria
