Biocompatible Xanthine-Quadruplex Scaffold for Ion-Transporting DNA Channels
Status PubMed-not-MEDLINE Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
26291860
DOI
10.1021/jz300559w
Knihovny.cz E-zdroje
- Klíčová slova
- adaptive biasing force, free-energy, guanine, ion transport, molecular dynamics,
- Publikační typ
- časopisecké články MeSH
Molecular dynamics simulations and adaptive biasing force analysis of the quadruplex DNA dynamics in an explicit solvent reveal fundamentally different mechanisms of Na(+) transport in xanthine- and guanine-based DNA systems. The barrier to the transport of K(+) through the xanthine-based quadruplex is significantly lower than those reported for the guanine-based analogs.
Citace poskytuje Crossref.org
