Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26363673
DOI
10.1016/j.parkreldis.2015.09.006
PII: S1353-8020(15)00381-8
Knihovny.cz E-resources
- Keywords
- Acoustic, Caudate nucleus, Dopaminergic, Functional connectivity, Levodopa, Motor speech network, Parkinson's disease, Resting state, Speech prosody, fMRI,
- MeSH
- Levodopa pharmacology therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Brain drug effects metabolism MeSH
- Nerve Net drug effects metabolism MeSH
- Neural Pathways drug effects metabolism MeSH
- Rest physiology MeSH
- Parkinson Disease diagnosis drug therapy metabolism MeSH
- Speech Disorders diagnosis drug therapy metabolism MeSH
- Speech drug effects physiology MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Levodopa MeSH
BACKGROUND: Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control. METHODS: We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis. RESULTS: The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody. CONCLUSIONS: We demonstrated an impact of PD but not of levodopa on rs-FC within the brain networks related to speech prosody control. When only the PD patients were taken into account, the association between treatment-induced changes in speech prosody and changes in rs-FC within the associative striato-prefrontal and motor speech networks was found.
References provided by Crossref.org
Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study
