AHEAD score--Long-term risk classification in acute heart failure
Language English Country Netherlands Media print-electronic
Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
PubMed
26386914
DOI
10.1016/j.ijcard.2015.08.187
PII: S0167-5273(15)30420-4
Knihovny.cz E-resources
- Keywords
- Acute heart failure, Model, Mortality, Prognosis,
- MeSH
- Acute Disease MeSH
- Time Factors MeSH
- Risk Assessment methods MeSH
- Incidence MeSH
- Humans MeSH
- Survival Rate trends MeSH
- Hospital Mortality trends MeSH
- Follow-Up Studies MeSH
- Predictive Value of Tests MeSH
- Cause of Death trends MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Registries * MeSH
- Reproducibility of Results MeSH
- Risk Factors MeSH
- Aged MeSH
- Cardiac Catheterization MeSH
- Heart Failure classification diagnosis epidemiology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
BACKGROUND: The role of co-morbidities in the prognosis of patients hospitalized for AHF was examined using the AHEAD (A--atrial fibrillation, H--haemoglobin<130 g/l for men and 120 g/l for women (anaemia), E--elderly (age>70years), A--abnormal renal parameters (creatinine>130 μmol/l), D--diabetes mellitus) scoring system. METHODS: AHEAD--multicentre prospective Czech registry of AHF patients; GREAT registry--international cohort of AHF patients. Data from 5846 consecutive patients hospitalized for AHF (AHEAD registry; derivation cohort) were analysed to build the AHEAD score. Each risk factor of the AHEAD score was counted as 1 point. The model was validated externally using an international cohort of similar patients in the GREAT registry (6315). RESULTS: Main outcome was one year all-cause mortality. The mean age of patients was 72±12 years, with 61.6% of patients aged >70 years; 43.4% were women. Atrial fibrillation was present in 30.7%, anaemia in 38.2%, creatinine>130 mmol/l (abnormal renal parameters) in 30.1%, and diabetes mellitus in 44.0%. The mean AHEAD score was 2.1. In patients with AHEAD scores of 0-5, the one-year mortality rates were 13.6%, 23.4%, 32.0%, 41.1%, 47.7%, and 58.2%, respectively (p<0.001), and the 90 month mortality rates were 35.1%, 57.3%, 73.5%, 84.8%, 88.0%, and 91.7%, respectively (p<0.001). CONCLUSION: The AHEAD is a simple scoring system based on the analysis of co-morbidities for the estimation of the short and long term prognosis of patients hospitalized for AHF.
Department of Cardiology Institute of Clinical and Experimental Medicine Prague Czech Republic
Department of Cardiology Na Homolce Hospital Prague Czech Republic
Department of Internal Medicine Hospital Frydek Mistek Frydek Mistek Czech Republic
Department of Internal Medicine University Hospital Olomouc Olomouc Czech Republic
Institute of Biostatistics and Analysis Faculty of Medicine Masaryk University Brno Czech Republic
References provided by Crossref.org
