Electrophysiology and colour: a comparison of methods to evaluate inner retinal function
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
26399726
DOI
10.1007/s10633-015-9512-z
PII: 10.1007/s10633-015-9512-z
Knihovny.cz E-zdroje
- Klíčová slova
- Diabetes, Diagnostic tests, Electroretinography, Glaucoma, Psychophysics, Retina,
- MeSH
- čípky retiny fyziologie MeSH
- citlivost na kontrast fyziologie MeSH
- diabetes mellitus 1. typu diagnóza patofyziologie MeSH
- diabetická retinopatie diagnóza patofyziologie MeSH
- dospělí MeSH
- elektrofyziologické jevy MeSH
- elektrofyziologie metody MeSH
- elektroretinografie metody MeSH
- glaukom diagnóza patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- poruchy barevného vidění diagnóza patofyziologie MeSH
- ROC křivka MeSH
- senioři MeSH
- senzorické prahy MeSH
- testy zrakového pole MeSH
- zraková pole fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
PURPOSE: Several methods are routinely used in the clinic to diagnose and monitor diseases of inner retinal function. In this study, we compare four such methods in patients with diabetes and glaucoma, to determine correlations between their results and to determine which method is most sensitive for detecting disease. METHODS: Twenty control subjects, 12 patients with early glaucoma and eight patients with diabetes mellitus, were enrolled in the study. All underwent four examinations: transient pattern electroretinogram (PERG), multifocal pattern electroretinogram (mfPERG), chromatic contrast threshold measurements (protan and tritan), and blue-on-yellow short-wavelength automated perimetry (SWAP). RESULTS: For the total cohort of 40 subjects, the results show a significant correlation between the amplitudes of the PERG and those of the mfPERG, as well as between the tritan contrast thresholds and the SWAP MD. Furthermore, ROC analyses reveal that colour contrast thresholds could significantly distinguish between the patient and the control group. Glaucoma patients alone could also be distinguished. CONCLUSIONS: We conclude that the methods compared in this study show correlations between their results if they are testing same pathway or underling cells, and that the colour contrast threshold is the most sensitive method to detect early functional deficits in diabetic and glaucoma patients.
University Eye Hospital Hradec Králové Czech Republic
Werner Reichardt Centre for Integrative Neuroscience University of Tübingen Tübingen Germany
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