Electrophysiology and colour: a comparison of methods to evaluate inner retinal function
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
26399726
DOI
10.1007/s10633-015-9512-z
PII: 10.1007/s10633-015-9512-z
Knihovny.cz E-resources
- Keywords
- Diabetes, Diagnostic tests, Electroretinography, Glaucoma, Psychophysics, Retina,
- MeSH
- Retinal Cone Photoreceptor Cells physiology MeSH
- Contrast Sensitivity physiology MeSH
- Diabetes Mellitus, Type 1 diagnosis physiopathology MeSH
- Diabetic Retinopathy diagnosis physiopathology MeSH
- Adult MeSH
- Electrophysiological Phenomena MeSH
- Electrophysiology methods MeSH
- Electroretinography methods MeSH
- Glaucoma diagnosis physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Color Vision Defects diagnosis physiopathology MeSH
- ROC Curve MeSH
- Aged MeSH
- Sensory Thresholds MeSH
- Visual Field Tests MeSH
- Visual Fields physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
PURPOSE: Several methods are routinely used in the clinic to diagnose and monitor diseases of inner retinal function. In this study, we compare four such methods in patients with diabetes and glaucoma, to determine correlations between their results and to determine which method is most sensitive for detecting disease. METHODS: Twenty control subjects, 12 patients with early glaucoma and eight patients with diabetes mellitus, were enrolled in the study. All underwent four examinations: transient pattern electroretinogram (PERG), multifocal pattern electroretinogram (mfPERG), chromatic contrast threshold measurements (protan and tritan), and blue-on-yellow short-wavelength automated perimetry (SWAP). RESULTS: For the total cohort of 40 subjects, the results show a significant correlation between the amplitudes of the PERG and those of the mfPERG, as well as between the tritan contrast thresholds and the SWAP MD. Furthermore, ROC analyses reveal that colour contrast thresholds could significantly distinguish between the patient and the control group. Glaucoma patients alone could also be distinguished. CONCLUSIONS: We conclude that the methods compared in this study show correlations between their results if they are testing same pathway or underling cells, and that the colour contrast threshold is the most sensitive method to detect early functional deficits in diabetic and glaucoma patients.
University Eye Hospital Hradec Králové Czech Republic
Werner Reichardt Centre for Integrative Neuroscience University of Tübingen Tübingen Germany
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