We report toxic effects of a photoactivatable platinum(IV) complex conjugated with suberoyl-bis-hydroxamic acid in tumor cells. The conjugate exerts, after photoactivation, two functions: activity as both a platinum(II) anticancer drug and histone deacetylase (HDAC) inhibitor in cancer cells. This approach relies on the use of a Pt(IV) pro-drug, acting by two independent mechanisms of biological action in a cooperative manner, which can be selectively photoactivated to a cytotoxic species in and around a tumor, thereby increasing selectivity towards cancer cells. These results suggest that this strategy is a valuable route to design new platinum agents with higher efficacy for photodynamic anticancer chemotherapy.

Department of Biophysics Faculty of Science Palacky University in Olomouc 17 listopadu 12 77146 Olomouc

Institute of Biophysics Academy of Sciences of the Czech Republic v v i Kralovopolska 135 61265 Brno

Regional Centre of Advanced Technologies and Materials Department of Inorganic Chemistry Faculty of Science Palacky University in Olomouc 17 listopadu 12 77146 Olomouc

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