Role of family D ATP-binding cassette transporters (ABCD) in cancer
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
26517907
DOI
10.1042/bst20150114
PII: BST20150114
Knihovny.cz E-zdroje
- Klíčová slova
- ATP-binding cassette (ABC) transporters, cancer, differentiation, peroxisomes, progression,
- MeSH
- ABC transportéry genetika metabolismus MeSH
- adrenoleukodystrofie genetika metabolismus MeSH
- lidé MeSH
- mastné kyseliny metabolismus MeSH
- multigenová rodina genetika MeSH
- mutace MeSH
- nádory genetika metabolismus patologie MeSH
- peroxizomy metabolismus MeSH
- progrese nemoci MeSH
- regulace genové exprese u nádorů MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- ABC transportéry MeSH
- mastné kyseliny MeSH
ATP-binding cassette (ABC) transporters, belonging to the family D, are expressed in peroxisomes, endoplasmic reticulum or lysosomes. ABCD transporters play a role in transport of lipids, bile acids and vitamin B12 and associate with peroxisomal disorders. ABCD1 performs transport of coenzyme A esters of very-long-chain fatty acids (VLCFA) in peroxisomes and a number of mutations in ABCD1 gene were linked to an X-linked adrenoleucodystrophy (X-ALD). The role of ABCD transporters in tumour growth has not been studied in detail, but there is some evidence that ABCDs levels differ between undifferentiated stem or tumour cells and differentiated cells suggesting a possible link to tumorigenesis. In this mini-review, we discuss the available information about the role of ABCD transporters in cancer.
Citace poskytuje Crossref.org
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