Role of family D ATP-binding cassette transporters (ABCD) in cancer
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26517907
DOI
10.1042/bst20150114
PII: BST20150114
Knihovny.cz E-resources
- Keywords
- ATP-binding cassette (ABC) transporters, cancer, differentiation, peroxisomes, progression,
- MeSH
- ATP-Binding Cassette Transporters genetics metabolism MeSH
- Adrenoleukodystrophy genetics metabolism MeSH
- Humans MeSH
- Fatty Acids metabolism MeSH
- Multigene Family genetics MeSH
- Mutation MeSH
- Neoplasms genetics metabolism pathology MeSH
- Peroxisomes metabolism MeSH
- Disease Progression MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- ATP-Binding Cassette Transporters MeSH
- Fatty Acids MeSH
ATP-binding cassette (ABC) transporters, belonging to the family D, are expressed in peroxisomes, endoplasmic reticulum or lysosomes. ABCD transporters play a role in transport of lipids, bile acids and vitamin B12 and associate with peroxisomal disorders. ABCD1 performs transport of coenzyme A esters of very-long-chain fatty acids (VLCFA) in peroxisomes and a number of mutations in ABCD1 gene were linked to an X-linked adrenoleucodystrophy (X-ALD). The role of ABCD transporters in tumour growth has not been studied in detail, but there is some evidence that ABCDs levels differ between undifferentiated stem or tumour cells and differentiated cells suggesting a possible link to tumorigenesis. In this mini-review, we discuss the available information about the role of ABCD transporters in cancer.
References provided by Crossref.org
ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer
