Potential of agricultural fungicides for antifungal drug discovery
Language English Country Great Britain, England Media print-electronic
Document type Editorial, Research Support, Non-U.S. Gov't
- Keywords
- agricultural fungicides, antifungal drugs, drug design and discovery, drug-likeness, lead-likeness, mycoses,
- MeSH
- Agrochemicals chemistry pharmacology MeSH
- Antifungal Agents chemistry pharmacology MeSH
- Fungi drug effects MeSH
- Humans MeSH
- Mycoses drug therapy MeSH
- Drug Discovery methods MeSH
- Fungicides, Industrial chemistry pharmacology MeSH
- Drug Design MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Editorial MeSH
- Names of Substances
- Agrochemicals MeSH
- Antifungal Agents MeSH
- Fungicides, Industrial MeSH
While it is true that only a small fraction of fungal species are responsible for human mycoses, the increasing prevalence of fungal diseases has highlighted an urgent need to develop new antifungal drugs, especially for systemic administration. This contribution focuses on the similarities between agricultural fungicides and drugs. Inorganic, organometallic and organic compounds can be found amongst agricultural fungicides. Furthermore, fungicides are designed and developed in a similar fashion to drugs based on similar rules and guidelines, with fungicides also having to meet similar criteria of lead-likeness and/or drug-likeness. Modern approved specific-target fungicides are well-characterized entities with a proposed structure-activity relationships hypothesis and a defined mode of action. Extensive toxicological evaluation, including mammalian toxicology assays, is performed during the whole discovery and development process. Thus modern agrochemical research (design of modern agrochemicals) comes close to drug design, discovery and development. Therefore, modern specific-target fungicides represent excellent lead-like structures/models for novel drug design and development.
References provided by Crossref.org
Advances in Nanostructures for Antimicrobial Therapy
Novel Sulfonamide-Based Carbamates as Selective Inhibitors of BChE
Photosynthesis-Inhibiting Activity of N-(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides
Synthesis and Spectrum of Biological Activities of Novel N-arylcinnamamides
