Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26772723
DOI
10.1016/j.cca.2016.01.005
PII: S0009-8981(16)30005-5
Knihovny.cz E-resources
- Keywords
- Cardiovascular disease, Polymorphism, Slavic population, Young,
- MeSH
- Genetic Variation genetics MeSH
- Genotype MeSH
- Body Mass Index MeSH
- Myocardial Infarction genetics MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human, Pair 2 genetics MeSH
- Chromosomes, Human, Pair 9 genetics MeSH
- Risk Factors MeSH
- Aging MeSH
- Age Factors MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
AIM: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. This study aimed to confirm the effect of common putative CVD-associated gene variants (FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (< 50 years) and older CVD patients. METHODS: 1191 controls and 1889 MI patients were analyzed. All participants were Caucasian Czech males aged <65 years (532 were <50 years) who were examined at cardiology clinics in Prague, Czech Republic. Variants of FTO, 9p21, 2q36.3, and KIF-6 were genotyped using PCR-RFLP or TaqMan assay. RESULTS: Variants of FTO (OR 1.48; 95% CI, 1.19-1.84 in a TT vs. GG comparison, p=0.0005); 9p21 (OR 1.74; 95% CI, 1.41-2.14 in an AA vs. GG comparison, p=0.0001); and 2q36.3 (OR 1.34; 95%CI, 1.09-1.65 in an AA vs. +C comparison, p=0.006) were significantly associated with MI in the male Czech population. In contrast, genotype frequencies of KIF-6 (rs20455) were the same in patients and controls (P=1.00). Nearly identical results were observed when a subset of young MI patients (N=532, aged <50 years) was analyzed. CONCLUSION: We confirmed the importance of determining FTO, 9p21, and 2q36.3 variants as part of the genetic determination of MI risk in the Czech male population.
References provided by Crossref.org
APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males
Epitranscriptomic Regulations in the Heart
Cholesterol associated genetic risk score and acute coronary syndrome in Czech males
RNA modification m6Am: the role in cardiac biology
