The Role of Airway and Endobronchial Ultrasound in Perioperative Medicine
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
26788507
PubMed Central
PMC4692981
DOI
10.1155/2015/754626
Knihovny.cz E-zdroje
- MeSH
- epiglotis diagnostické zobrazování MeSH
- hlasové řasy diagnostické zobrazování patologie MeSH
- intratracheální intubace MeSH
- laryngální masky MeSH
- lidé MeSH
- nemoci průdušnice diagnostické zobrazování patologie chirurgie MeSH
- perioperační péče * MeSH
- rázové vlny s vysokou energií MeSH
- trachea diagnostické zobrazování patologie chirurgie MeSH
- tracheostomie MeSH
- ultrasonografie MeSH
- ústa diagnostické zobrazování patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Recent years have witnessed an increased use of ultrasound in evaluation of the airway and the lower parts of the respiratory system. Ultrasound examination is fast and reliable and can be performed at the bedside and does not carry the risk of exposure to ionizing radiation. Apart from use in diagnostics it may also provide safe guidance for invasive and semi-invasive procedures. Ultrasound examination of the oral cavity structures, epiglottis, vocal cords, and subglottic space may help in the prediction of difficult intubation. Preoperative ultrasound may diagnose vocal cord palsy or deviation or stenosis of the trachea. Ultrasonography can also be used for confirmation of endotracheal tube, double-lumen tube, or laryngeal mask placement. This can be achieved by direct examination of the tube inside the trachea or by indirect methods evaluating lung movements. Postoperative airway ultrasound may reveal laryngeal pathology or subglottic oedema. Conventional ultrasound is a reliable real-time navigational tool for emergency cricothyrotomy or percutaneous dilational tracheostomy. Endobronchial ultrasound is a combination of bronchoscopy and ultrasonography and is used for preoperative examination of lung cancer and solitary pulmonary nodules. The method is also useful for real-time navigated biopsies of such pathological structures.
Zobrazit více v PubMed
Meyer R. A. History of ultrasound in cardiology. Journal of Ultrasound in Medicine. 2004;23(1):1–11. PubMed
Kristensen M. S. Ultrasonography in the management of the airway. Acta Anaesthesiologica Scandinavica. 2011;55(10):1155–1173. doi: 10.1111/j.1399-6576.2011.02518.x. PubMed DOI
Beaudoin E.-L., Chee A., Stather D. R. Interventional pulmonology: an update for internal medicine physicians. Minerva Medica. 2014;105(3):197–209. PubMed
Kundra P., Mishra S. K., Ramesh A. Ultrasound of the airway. Indian Journal of Anaesthesia. 2011;55(5):456–462. doi: 10.4103/0019-5049.89868. PubMed DOI PMC
Chou E. H., Dickman E., Tsou P. Y., et al. Ultrasonography for confirmation of endotracheal tube placement: a systematic review and meta-analysis. Resuscitation. 2015;90(1):97–103. doi: 10.1016/j.resuscitation.2015.02.013. PubMed DOI
Alansari M., Alotair H., Al Aseri Z., Elhoseny M. A. Use of ultrasound guidance to improve the safety of percutaneous dilatational tracheostomy: a literature review. Critical Care. 2015;19, article 229 doi: 10.1186/s13054-015-0942-5. PubMed DOI PMC
Tsui P.-H., Wan Y.-L., Chen C.-K. Ultrasound imaging of the larynx and vocal folds: recent applications and developments. Current Opinion in Otolaryngology and Head and Neck Surgery. 2012;20(6):437–442. doi: 10.1097/moo.0b013e32835896b4. PubMed DOI
Terkawi A. S., Karakitsos D., Elbarbary M., Blaivas M., Durieux M. E. Ultrasound for the anesthesiologists: present and future. The Scientific World Journal. 2013;2013:15. doi: 10.1155/2013/683685.683685 PubMed DOI PMC
Law C. P., Chandra R. V., Hoang J. K., Phal P. Imaging the oral cavity: key concepts for the radiologist. British Journal of Radiology. 2011;84(1006):944–957. doi: 10.1259/bjr/70520972. PubMed DOI PMC
Adamus M., Jor O., Vavreckova T., et al. Inter-observer reproducibility of 15 tests used for predicting difficult intubation. Biomedical Papers. 2011;155(3):275–282. doi: 10.5507/bp.2011.041. PubMed DOI
Tsui B. C. H., Hui C. M. W. Challenges in sublingual airway ultrasound interpretation. Canadian Journal of Anesthesia. 2009;56(5):393–394. doi: 10.1007/s12630-009-9077-y. PubMed DOI
Khalil T., Madian Y., Farid A. High resolution laryngeal ultrasound for diagnosis of vocal cords lesions. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2010;11(3):64–68.
Tsui P.-H., Chang C.-C. Imaging local scatterer concentrations by the Nakagami statistical model. Ultrasound in Medicine and Biology. 2007;33(4):608–619. doi: 10.1016/j.ultrasmedbio.2006.10.005. PubMed DOI
Lakhal K., Delplace X., Cottier J.-P., et al. The feasibility of ultrasound to assess subglottic diameter. Anesthesia & Analgesia. 2007;104(3):611–614. doi: 10.1213/01.ane.0000260136.53694.fe. PubMed DOI
Ezri T., Gewürtz G., Sessler D. I., et al. Prediction of difficult laryngoscopy in obese patients by ultrasound quantification of anterior neck soft tissue. Anaesthesia. 2003;58(11):1111–1114. doi: 10.1046/j.1365-2044.2003.03412.x. PubMed DOI PMC
Komatsu R., Sengupta P., Wadhwa A., et al. Ultrasound quantification of anterior soft tissue thickness fails to predict difficult laryngoscopy in obese patients. Anaesthesia and Intensive Care. 2007;35(1):32–37. PubMed
Wu J., Dong J., Ding Y., Zheng J. Role of anterior neck soft tissue quantifications by ultrasound in predicting difficult laryngoscopy. Medical Science Monitor. 2014;20:2343–2350. doi: 10.12659/msm.891037. PubMed DOI PMC
Hui C. M., Tsui B. C. Sublingual ultrasound as an assessment method for predicting difficult intubation: a pilot study. Anaesthesia. 2014;69(4):314–319. doi: 10.1111/anae.12598. PubMed DOI
Wojtczak J. A. Submandibular sonography: assessment of hyomental distances and ratio, tongue size, and floor of the mouth musculature using portable sonography. Journal of Ultrasound in Medicine. 2012;31(4):523–528. PubMed
Miles K. A. Ultrasound demonstration of vocal cord movements. British Journal of Radiology. 1989;62(741):871–872. doi: 10.1259/0007-1285-62-741-871. PubMed DOI
Kundra P., Kumar K., Allampalli V., Anathkrishnan R., Gopalakrishnan S., Elangovan S. Use of ultrasound to assess superior and recurrent laryngeal nerve function immediately after thyroid surgery. Anaesthesia. 2012;67(3):301–302. doi: 10.1111/j.1365-2044.2012.07064.x. PubMed DOI
Wong K.-P., Lang B. H.-H., Ng S.-H., Cheung C.-Y., Chan C. T.-Y., Chan M.-Y. Is vocal cord asymmetry seen on transcutaneous laryngeal ultrasonography a significant predictor of voice quality changes after thyroidectomy? World Journal of Surgery. 2014;38(3):607–613. doi: 10.1007/s00268-013-2337-6. PubMed DOI
Wang C.-P., Chen T.-C., Yang T.-L., et al. Transcutaneous ultrasound for evaluation of vocal fold movement in patients with thyroid disease. European Journal of Radiology. 2012;81(3):e288–e291. doi: 10.1016/j.ejrad.2011.09.020. PubMed DOI
Carneiro-Pla D., Miller B. S., Wilhelm S. M., et al. Feasibility of surgeon-performed transcutaneous vocal cord ultrasonography in identifying vocal cord mobility: a multi-institutional experience. Surgery. 2014;156(6):1597–1602. doi: 10.1016/j.surg.2014.08.071. PubMed DOI
Ding L.-W., Wang H.-C., Wu H.-D., Chang C.-J., Yang P.-C. Laryngeal ultrasound: a useful method in predicting post-extubation stridor. A pilot study. European Respiratory Journal. 2006;27(2):384–389. doi: 10.1183/09031936.06.00029605. PubMed DOI
Mikaeili H., Yazdchi M., Tarzamni M. K., Ansarin K., Ghasemzadeh M. Laryngeal ultrasonography versus cuff leak test in predicting postextubation stridor. Journal of Cardiovascular and Thoracic Research. 2014;6(1):25–28. PubMed PMC
Cheng S.-P., Lee J.-J., Liu T.-P., Lee K.-S., Liu C.-L. Preoperative ultrasonography assessment of vocal cord movement during thyroid and parathyroid surgery. World Journal of Surgery. 2012;36(10):2509–2515. doi: 10.1007/s00268-012-1674-1. PubMed DOI
Amis R. J., Gupta D., Dowdall J. R., Srirajakalindini A., Folbe A. Ultrasound assessment of vocal fold paresis: a correlation case series with flexible fiberoptic laryngoscopy and adding the third dimension (3-D) to vocal fold mobility assessment. Middle East Journal of Anesthesiology. 2012;21(4):493–498. PubMed
Rubin J. S., Lee S., McGuinness J., Hore I., Hill D., Berger L. The potential role of ultrasound in differentiating solid and cystic swellings of the true vocal fold. Journal of Voice. 2004;18(2):231–235. doi: 10.1016/S0892-1997(03)00035-3. PubMed DOI
Sirikci A., Karatas E., Durucu C., et al. Noninvasive assessment of benign lesions of vocal folds by means of ultrasonography. Annals of Otology, Rhinology and Laryngology. 2007;116(11):827–831. doi: 10.1177/000348940711601106. PubMed DOI
Garel C., Hassan M., Legrand I., Elmaleh M., Narcy P. Laryngeal ultrasonography in infants and children: pathological findings. Pediatric Radiology. 1991;21(3):164–167. doi: 10.1007/bf02011037. PubMed DOI
Spadola Bisetti M., Segala F., Zappia F., Albera R., Ottaviani F., Schindler A. Non-invasive assessment of benign vocal folds lesions in children by means of ultrasonography. International Journal of Pediatric Otorhinolaryngology. 2009;73(8):1160–1162. doi: 10.1016/j.ijporl.2009.05.004. PubMed DOI
Liberty G., Boldes R., Shen O., Shaul C., Cohen S. M., Yagel S. The fetal larynx and pharynx: structure and development on two- and three-dimensional ultrasound. Ultrasound in Obstetrics and Gynecology. 2013;42(2):140–148. doi: 10.1002/uog.12358. PubMed DOI
Giguere C. M., Manoukian J. J., Patenaude Y., Platt R. Ultrasound and a new videobronchoscopic technique to measure the subglottic diameter. Journal of Otolaryngology. 2000;29(5):290–298. PubMed
Husein M., Manoukian J. J., Platt R., Patenaude Y., Drouin S., Giguère C. Ultrasonography and videobronchoscopy to assess the subglottic diameter in the paediatric population: a first look. Journal of Otolaryngology. 2002;31(4):220–226. doi: 10.2310/7070.2002.21697. PubMed DOI
Shibasaki M., Nakajima Y., Ishii S., Shimizu F., Shime N., Sessler D. I. Prediction of pediatric endotracheal tube size by ultrasonography. Anesthesiology. 2010;113(4):819–824. doi: 10.1097/aln.0b013e3181ef6757. PubMed DOI
Schramm C., Knop J., Jensen K., Plaschke K. Role of ultrasound compared to age-related formulas for uncuffed endotracheal intubation in a pediatric population. Paediatric Anaesthesia. 2012;22(8):781–786. doi: 10.1111/j.1460-9592.2012.03889.x. PubMed DOI
Kim E. J., Kim S. Y., Kim W. O., Kim H., Kil H. K. Ultrasound measurement of subglottic diameter and an empirical formula for proper endotracheal tube fitting in children. Acta Anaesthesiologica Scandinavica. 2013;57(9):1124–1130. doi: 10.1111/aas.12167. PubMed DOI
Bae J.-Y., Byon H.-J., Han S.-S., Kim H.-S., Kim J.-T. Usefulness of ultrasound for selecting a correctly sized uncuffed tracheal tube for paediatric patients. Anaesthesia. 2011;66(11):994–998. doi: 10.1111/j.1365-2044.2011.06900.x. PubMed DOI
Or D. Y. L., Karmakar M. K., Lam G. C. S., Hui J. W. Y., Li J. W., Chen P. P. Multiplanar 3d ultrasound imaging to assess the anatomy of the upper airway and measure the subglottic and tracheal diameters in adults. British Journal of Radiology. 2013;86(1030) doi: 10.1259/bjr.20130253.20130253 PubMed DOI PMC
Eicken J. J., Wilcox S. R., Liteplo A. S. Bedside sonographic diagnosis of tracheal stenosis. Journal of Ultrasound in Medicine. 2012;31(9):1468–1470. PubMed
El-Anwar M. W., Amer H. S., Herzallah I. R., El-Gerby K. M. Assessment of laryngeal ultrasound feasibility in evaluating subglottic stenosis. Medical Journal of Cairo University. 2014;82(2):33–37.
Werner S. L., Smith C. E., Goldstein J. R., Jones R. A., Cydulka R. K. Pilot study to evaluate the accuracy of ultrasonography in confirming endotracheal tube placement. Annals of Emergency Medicine. 2007;49(1):75–80. doi: 10.1016/j.annemergmed.2006.07.004. PubMed DOI
Abbasi S., Farsi D., Zare M. A., Hajimohammadi M., Rezai M., Hafezimoghadam P. Direct ultrasound methods: a confirmatory technique for proper endotracheal intubation in the emergency department. European Journal of Emergency Medicine. 2015;22(1):10–16. doi: 10.1097/mej.0000000000000108. PubMed DOI
Adi O., Chuan T. W., Rishya M. A feasibility study on bedside upper airway ultrasonography compared to waveform capnography for verifying endotracheal tube location after intubation. Critical Ultrasound Journal. 2013;5(1, article 7) PubMed PMC
Chou H.-C., Tseng W.-P., Wang C.-H., et al. Tracheal rapid ultrasound exam (T.R.U.E.) for confirming endotracheal tube placement during emergency intubation. Resuscitation. 2011;82(10):1279–1284. doi: 10.1016/j.resuscitation.2011.05.016. PubMed DOI
Chou H.-C., Chong K.-M., Sim S.-S., et al. Real-time tracheal ultrasonography for confirmation of endotracheal tube placement during cardiopulmonary resuscitation. Resuscitation. 2013;84(12):1708–1712. doi: 10.1016/j.resuscitation.2013.06.018. PubMed DOI
Muslu B., Sert H., Kaya A., et al. Use of sonography for rapid identification of esophageal and tracheal intubations in adult patients. Journal of Ultrasound in Medicine. 2011;30(5):671–676. PubMed
Weaver B., Lyon M., Blaivas M. Confirmation of endotracheal tube placement after intubation using the ultrasound sliding lung sign. Academic Emergency Medicine. 2006;13(3):239–244. doi: 10.1197/j.aem.2005.08.014. PubMed DOI
Hosseini J. S., Talebian M. T., Ghafari M. H., Eslami V. Secondary confirmation of endotracheal tube position by diaphragm motion in right subcostal ultrasound view. International Journal of Critical Illness and Injury Science. 2013;3(2):113–117. doi: 10.4103/2229-5151.114269. PubMed DOI PMC
Park S. C., Ryu J. H., Yeom S. R., Jeong J. W., Cho S. J. Confirmation of endotracheal intubation by combined ultrasonographic methods in the emergency department. Emergency Medicine Australasia. 2009;21(4):293–297. doi: 10.1111/j.1742-6723.2009.01199.x. PubMed DOI
Saporito A., Lo Piccolo A., Franceschini D., Tomasetti R., Anselmi L. Thoracic ultrasound confirmation of correct lung exclusion before one-lung ventilation during thoracic surgery. Journal of Ultrasound. 2013;16(4):195–199. doi: 10.1007/s40477-013-0050-9. PubMed DOI PMC
Kim J., Kim J. Y., Kim W. O., Kil H. K. An ultrasound evaluation of laryngeal mask airway position in pediatric patients: an observational study. Anesthesia & Analgesia. 2015;120(2):427–432. doi: 10.1213/ane.0000000000000551. PubMed DOI
Henlin T., Michalek P., Tyll T., Hinds J. D., Dobias M. Oxygenation, ventilation, and airway management in out-of-hospital cardiac arrest: a review. BioMed Research International. 2014;2014:11. doi: 10.1155/2014/376871.376871 PubMed DOI PMC
Bair A. E., Chima R. The inaccuracy of using landmark techniques for cricothyroid membrane identification: a comparison of three techniques. Academic Emergency Medicine. 2015;22(8):908–914. doi: 10.1111/acem.12732. PubMed DOI
You-Ten K. E., Desai D., Postonogova T., Siddiqui N. Accuracy of conventional digital palpation and ultrasound of the cricothyroid membrane in obese women in labour. Anaesthesia. 2015;70(11):1230–1234. doi: 10.1111/anae.13167. PubMed DOI
Campbell M., Shanahan H., Ash S., Royds J., Husarova V., McCaul C. The accuracy of locating the cricothyroid membrane by palpation—an intergender study. BMC Anesthesiology. 2014;14, article 108 doi: 10.1186/1471-2253-14-108. PubMed DOI PMC
Aslani A., Ng S.-C., Hurley M., McCarthy K. F., McNicholas M., McCaul C. L. Accuracy of identification of the cricothyroid membrane in female subjects using palpation: an observational study. Anesthesia & Analgesia. 2012;114(5):987–992. doi: 10.1213/ane.0b013e31824970ba. PubMed DOI
Curtis K., Ahern M., Dawson M., Mallin M. Ultrasound-guided, bougie-assisted cricothyroidotomy: a description of a novel technique in cadaveric models. Academic Emergency Medicine. 2012;19(7):876–879. doi: 10.1111/j.1553-2712.2012.01391.x. PubMed DOI
Suzuki A., Iida T., Kunisawa T., Henderson J. J., Fujita S., Iwasaki H. Ultrasound-guided cannula cricothyroidotomy. Anesthesiology. 2012;117(5, article 1128) doi: 10.1097/aln.0b013e3182531a6c. PubMed DOI
Nicholls S. E., Sweeney T. W., Ferre R. M., Strout T. D. Bedside sonography by emergency physicians for the rapid identification of landmarks relevant to cricothyrotomy. American Journal of Emergency Medicine. 2008;26(8):852–856. doi: 10.1016/j.ajem.2007.11.022. PubMed DOI
Bertram S., Emshoff R., Norer B. Ultrasonographic anatomy of the anterior neck: implications for tracheostomy. Journal of Oral and Maxillofacial Surgery. 1995;53(12):1420–1424. doi: 10.1016/0278-2391(95)90669-x. PubMed DOI
Hatfield A., Bodenham A. Portable ultrasonic scanning of the anterior neck before percutaneous dilatational tracheostomy. Anaesthesia. 1999;54(7):660–663. doi: 10.1046/j.1365-2044.1999.00859.x. PubMed DOI
Muhammad J. K., Patton D. W., Evans R. M., Major E. Percutaneous dilatational tracheostomy under ultrasound guidance. British Journal of Oral and Maxillofacial Surgery. 1999;37(4):309–311. doi: 10.1054/bjom.1999.0072. PubMed DOI
Kollig E., Heydenreich U., Roetman B., Hopf F., Muhr G. Ultrasound and bronchoscopic controlled percutaneous tracheostomy on trauma ICU. Injury. 2000;31(9):663–668. doi: 10.1016/s0020-1383(00)00094-2. PubMed DOI
Flint A. C., Midde R., Rao V. A., Lasman T. E., Ho P. T. Bedside ultrasound screening for pretracheal vascular structures may minimize the risks of percutaneous dilatational tracheostomy. Neurocritical Care. 2009;11(3):372–376. doi: 10.1007/s12028-009-9259-z. PubMed DOI
Kleine-Brueggeney M., Greif R., Ross S., et al. Ultrasound-guided percutaneous tracheal puncture: a computer-tomographic controlled study in cadavers. British Journal of Anaesthesia. 2011;106(5):738–742. doi: 10.1093/bja/aer026. PubMed DOI
Dinh V. A., Farshidpanah S., Lu S., et al. Real-time sonographically guided percutaneous dilatational tracheostomy using a long-axis approach compared to the landmark technique. Journal of Ultrasound in Medicine. 2014;33(8):1407–1415. doi: 10.7863/ultra.33.8.1407. PubMed DOI
Rudas M., Seppelt I., Herkes R., Hislop R., Rajbhandari D., Weisbrodt L. Traditional landmark versus ultrasound guided tracheal puncture during percutaneous dilatational tracheostomy in adult intensive care patients: a randomised controlled trial. Critical Care. 2014;18, article 514 doi: 10.1186/s13054-014-0514-0. PubMed DOI PMC
Gobatto A. L. N., Besen B. A. M. P., Tierno P. F. G. M. M., et al. Comparison between ultrasound- and bronchoscopy-guided percutaneous dilational tracheostomy in critically ill patients: a retrospective cohort study. Journal of Critical Care. 2015;30(1):220.e13–220.e17. doi: 10.1016/j.jcrc.2014.09.011. PubMed DOI
Rajajee V., Williamson C. A., West B. T. Impact of real-time ultrasound guidance on complications of percutaneous dilatational tracheostomy: a propensity score analysis. Critical Care. 2015;19, article 198 doi: 10.1186/s13054-015-0924-7. PubMed DOI PMC
Sheski F. D., Mathur P. N. Endobronchial ultrasound. Chest. 2008;133(1):264–270. doi: 10.1378/chest.06-1735. PubMed DOI
Harrow E. M., Abi-Saleh W., Blum J., et al. The utility of transbronchial needle aspiration in the staging of bronchogenic carcinoma. American Journal of Respiratory and Critical Care Medicine. 2000;161(2):601–607. doi: 10.1164/ajrccm.161.2.9902040. PubMed DOI
Holty J.-E. C., Kuschner W. G., Gould M. K. Accuracy of transbronchial needle aspiration for mediastinal staging of non-small cell lung cancer: a meta-analysis. Thorax. 2005;60(11):949–955. doi: 10.1136/thx.2005.041525. PubMed DOI PMC
Gex G., Pralong J. A., Combescure C., Seijo L., Rochat T., Soccal P. M. Diagnostic yield and safety of electromagnetic navigation bronchoscopy for lung nodules: a systematic review and meta-analysis. Respiration. 2014;87(2):165–176. doi: 10.1159/000355710. PubMed DOI
Becker H. D. EBUS: a new dimension in bronchoscopy of sounds and images—a paradigm of innovation. Respiration. 2006;73(5):583–586. doi: 10.1159/000095312. PubMed DOI
Herth F., Ernst A., Schulz M., Becker H. Endobronchial ultrasound reliably differentiates between airway infiltration and compression by tumor. Chest. 2003;123(2):458–462. doi: 10.1378/chest.123.2.458. PubMed DOI
Dolan A. M., Moore M. F. Anaesthesia for tracheobronchial stent insertion using an laryngeal mask airway and high-frequency jet ventilation. Case Reports in Medicine. 2013;2013:5. doi: 10.1155/2013/950437.950437 PubMed DOI PMC
Donaldson W., Abraham A., Deighan M., Michalek P. I-GEL vs. auraonce laryngeal mask for general anaesthesia with controlled ventilation in paralyzed patients. Biomedical Papers. 2011;155(2):155–164. doi: 10.5507/bp.2011.023. PubMed DOI
Schuhmann M., Eberhardt R., Herth F. J. F. Endobronchial ultrasound for peripheral lesions: a review. Endoscopic Ultrasound. 2013;2(1):3–6. doi: 10.7178/eus.04.002. PubMed DOI PMC
Paone G., Nicastri E., Lucantoni G., et al. Endobronchial ultrasound-driven biopsy in the diagnosis of peripheral lung lesions. Chest. 2005;128(5):3551–3557. doi: 10.1378/chest.128.5.3551. PubMed DOI
Eberhardt R., Kahn N., Herth F. J. F. ‘Heat and Destroy’: bronchoscopic-guided therapy of peripheral lung lesions. Respiration. 2010;79(4):265–273. doi: 10.1159/000284015. PubMed DOI
Detterbeck F. C., Mazzone P. J., Naidich D. P., Bach P. B. Screening for lung cancer: diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2013;143(supplement 5):e78s–e92s. doi: 10.1378/chest.12-2350. PubMed DOI PMC