Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats
Molecular nutrition & food research.
2016 May ;
60 (5) :
981-91.
[epub] 20160223
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/pmid26790841
- Keywords
- Blood pressure, Flavonoid, Metabolite, Phenolic, Quercetin, Rat, Vascular,
- MeSH
- Arterial Pressure drug effects MeSH
- Phenols pharmacology MeSH
- Flavonoids pharmacology MeSH
- Hemodynamics MeSH
- Rats MeSH
- Humans MeSH
- Linear Models MeSH
- Rats, Inbred SHR MeSH
- Rats, Wistar MeSH
- Propionates pharmacology MeSH
- Gastrointestinal Microbiome MeSH
- Tandem Mass Spectrometry MeSH
- In Vitro Techniques MeSH
- Chromatography, High Pressure Liquid MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 3-hydroxyphenylpropionic acid MeSH Browser
- Phenols MeSH
- Flavonoids MeSH
- Propionates MeSH
There are reports of positive effects of quercetin on cardiovascular pathologies, however, mainly due to its low biovailability, the mechanism remains elusive. Here, we report that one metabolite formed by human microflora (3-(3-hydroxyphenyl)propionic acid)relaxed isolated rat aorta and decreased arterial blood pressure in rats.
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