Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26863184
DOI
10.1016/j.envint.2016.01.021
PII: S0160-4120(16)30021-6
Knihovny.cz E-resources
- Keywords
- Bisphenol A, Endocrine disruptor, Polychlorinated biphenyls, Reproduction, Spermatogenesis, Steroid,
- MeSH
- Benzhydryl Compounds analysis blood toxicity MeSH
- Chromatography, Liquid methods MeSH
- Adult MeSH
- Endocrine Disruptors analysis blood toxicity MeSH
- Phenols analysis blood toxicity MeSH
- Humans MeSH
- Infertility, Male blood chemically induced epidemiology MeSH
- Sperm Count MeSH
- Gonadal Steroid Hormones blood MeSH
- Polychlorinated Biphenyls analysis blood toxicity MeSH
- Semen chemistry drug effects MeSH
- Spermatogenesis drug effects MeSH
- Spermatozoa chemistry drug effects pathology MeSH
- Testosterone blood MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Benzhydryl Compounds MeSH
- bisphenol A MeSH Browser
- Endocrine Disruptors MeSH
- Phenols MeSH
- Gonadal Steroid Hormones MeSH
- Polychlorinated Biphenyls MeSH
- Testosterone MeSH
BACKGROUND: In the testis, steroid hormones play an important role in spermatogenesis, the production of semen, and the maintenance of secondary sex characteristics and libido. They may also play a role as a target for substances called endocrine disruptors (EDs). As yet, however, no complex study has been conducted evaluating the relationships between EDs and the steroid spectrum in the plasma and seminal plasma. OBJECTIVES: To shed more light into mechanisms of EDs and the effects of bisphenol A (BPA) and polychlorinated biphenyls (PCBs) on human spermatogenesis and steroidogenesis. METHODS: We determined BPA and 11 steroids in the plasma and seminal plasma of 191 men with different degrees of fertility, using a newly developed liquid-chromatography mass spectrometry method. Concurrently, plasma levels of 6 congeners of PCBs, gonadotropins, selenium, zinc and homocysteine were measured. Partial correlations adjusted for age, BMI and abstinence time were performed to evaluate relationships between these analytes. RESULTS: Seminal BPA, but not plasma BPA, was negatively associated with sperm concentration (r=-0.198; p=0.009), sperm count (r=-0.178; p=0.018) and morphology (r=-0.160; p=0.044). Divergent and sometimes opposing associations of steroids and BPA were found in both body fluids. The sum of PCB congeners was negatively associated with testosterone, free testosterone, the free androgen index and dihydrotestosterone in plasma. CONCLUSION: BPA may negatively contribute to the final state of sperm quality. Moreover, our data indicate that BPA influences human gonadal and adrenal steroidogenesis at various steps. Environmental levels of PCBs negatively correlated with androgen levels, but surprisingly without negative effects on sperm quality.
Department of Steroids and Proteofactors Institute of Endocrinology Prague Czech Republic
Department of Urology 3rd Faculty of Medicine Charles University Prague Czech Republic
References provided by Crossref.org
The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes
Endocrine disruptors and gut microbiome interactions
Steroid diagnostics of 21st century in the light of their new roles and analytical tools
Occurrence and reproductive roles of hormones in seminal plasma
