The role of the endoplasmic reticulum stress in stemness, pluripotency and development
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26905505
DOI
10.1016/j.ejcb.2016.02.002
PII: S0171-9335(16)30005-X
Knihovny.cz E-resources
- Keywords
- Development, Embryonic stem cells, Endoplasmic reticulum stress, Pluripotency, Unfolded protein response,
- MeSH
- Cell Differentiation * MeSH
- Embryonic Development * MeSH
- Homeostasis MeSH
- Humans MeSH
- Pluripotent Stem Cells cytology metabolism MeSH
- Endoplasmic Reticulum Stress * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.
References provided by Crossref.org
