The role of the endoplasmic reticulum stress in stemness, pluripotency and development

. 2016 Mar-May ; 95 (3-5) : 115-23. [epub] 20160206

Jazyk angličtina Země Německo Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/pmid26905505
Odkazy

PubMed 26905505
DOI 10.1016/j.ejcb.2016.02.002
PII: S0171-9335(16)30005-X
Knihovny.cz E-zdroje

The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.

Citace poskytuje Crossref.org

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