Aerobic mitochondria of parasitic protists: Diverse genomes and complex functions
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review
PubMed
26906976
DOI
10.1016/j.molbiopara.2016.02.007
PII: S0166-6851(16)30015-9
Knihovny.cz E-resources
- Keywords
- Electron transport chain, Genomes, Heme, Iron–sulfur cluster, Mitochondrion, Protists, RNA editing, Replication, Ribosomes,
- MeSH
- RNA Editing MeSH
- Electron Transport Chain Complex Proteins metabolism MeSH
- Genome, Microbial * MeSH
- Heme metabolism MeSH
- Oxygen metabolism MeSH
- Mitochondrial Ribosomes metabolism MeSH
- Mitochondria genetics metabolism MeSH
- Parasites genetics metabolism MeSH
- DNA Replication MeSH
- RNA, Mitochondrial MeSH
- RNA genetics metabolism MeSH
- Sulfur metabolism MeSH
- Genomic Structural Variation MeSH
- Iron metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Electron Transport Chain Complex Proteins MeSH
- Heme MeSH
- Oxygen MeSH
- RNA, Mitochondrial MeSH
- RNA MeSH
- Sulfur MeSH
- Iron MeSH
In this review the main features of the mitochondria of aerobic parasitic protists are discussed. While the best characterized organelles are by far those of kinetoplastid flagellates and Plasmodium, we also consider amoebae Naegleria and Acanthamoeba, a ciliate Ichthyophthirius and related lineages. The simplistic view of the mitochondrion as just a power house of the cell has already been abandoned in multicellular organisms and available data indicate that this also does not apply for protists. We discuss in more details the following mitochondrial features: genomes, post-transcriptional processing, translation, biogenesis of iron-sulfur complexes, heme metabolism and the electron transport chain. Substantial differences in all these core mitochondrial features between lineages are compatible with the view that aerobic protists harbor organelles that are more complex and flexible than previously appreciated.
Charles University Prague Faculty of Science Prague Czech Republic
Institute of Parasitology Biology Centre České Budějovice Czech Republic
References provided by Crossref.org
Reductive evolution of chloroplasts in non-photosynthetic plants, algae and protists
From simple to supercomplex: mitochondrial genomes of euglenozoan protists
