The aim of this study project was to prepare our own method of porcine oesophageal manometry. Ten mature experimental pigs entered the study. Conventional water-perfused system was decided for manometry. Porcine resting and relaxed pressures of the lower oesophageal sphincter are fully comparable with healthy human subjects. Evocable swallowing is doable and oesophageal peristalsis is quantifiable. Basic manometric parameters were different in male and female animals. Oesophageal manometry in experimental pigs is feasible. Porcine oesophageal manometry will be usable for preclinical studies in future.

2nd Department of Internal Medicine Gastroenterology Charles University in Praha Faculty of Medicine at Hradec Králové University Hospital Hradec Králové Czech Republic

Animal Laboratory University of Defence Faculty of Military Health Sciences Hradec Králové Czech Republic

Institute of Experimental Biopharmaceutics Czech Academy of Sciences Hradec Králové Czech Republic

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