Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination
Language English Country Germany Media print-electronic
Document type Journal Article
PubMed
26996913
DOI
10.1007/s11356-016-6472-0
PII: 10.1007/s11356-016-6472-0
Knihovny.cz E-resources
- Keywords
- Albendazole, Anthelmintics, Ecotoxicity, Haemonchus contortus, Plants, Sheep, UHPLC/MS/MS,
- MeSH
- Albendazole analysis pharmacology MeSH
- Feces chemistry MeSH
- Haemonchus drug effects growth & development MeSH
- Sinapis drug effects growth & development MeSH
- Germination drug effects MeSH
- Sheep MeSH
- Seeds drug effects MeSH
- Tandem Mass Spectrometry MeSH
- Chromatography, High Pressure Liquid MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Albendazole MeSH
Albendazole (ABZ), widely used benzimidazole anthelmintic, administered to animals enters via excrements into environment and may impact non-target organisms. Moreover, exposure of lower development stages of helminths to anthelmintics may also encourage the development of drug-resistant strains of helminths. In present project, the kinetics of ABZ (10 mg kg(-1) p.o.) and its metabolite (ABZ.SO, ABZSO2) elimination in faeces from treated Texel lambs were studied using UHPLC/MS/MS with the aim to find out their concentrations achievable in the environment. Consequently, the effect of these compounds on lower development stages of Barber's pole worm (Haemonchus contortus) and on germination of white mustard (Sinapis alba) seeds was evaluated. The results showed that ABZ concentrations in faeces excreted in 4-60 h after treatment were above the concentrations lethal for H. contortus eggs. Moreover, pre-incubation with sub-lethal doses of ABZ and ABZ.SO did not increase the resistance of H. contortus eggs and larvae to anthelmintics. On the other hand, concentrations of ABZ and ABZ.SO in faeces are so high that might have negative influence on non-target soil invertebrates. As neither ABZ nor its metabolites affect the germination of mustard seeds, phytoremediation could be considered as potential tool for detoxification of ABZ in the environment.
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