Metabolic pathways of benzimidazole anthelmintics in harebell (Campanula rotundifolia)
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27208642
DOI
10.1016/j.chemosphere.2016.05.015
PII: S0045-6535(16)30644-0
Knihovny.cz E-zdroje
- Klíčová slova
- Albendazole, Biotransformation, Drug metabolism, Flubendazole, Phytoremediation,
- MeSH
- albendazol metabolismus MeSH
- anthelmintika chemie metabolismus MeSH
- benzimidazoly chemie metabolismus MeSH
- biotransformace MeSH
- Campanulaceae cytologie metabolismus MeSH
- ekosystém MeSH
- feces chemie MeSH
- fenbendazol metabolismus MeSH
- kultivované buňky MeSH
- mebendazol analogy a deriváty metabolismus MeSH
- metabolické sítě a dráhy * MeSH
- tandemová hmotnostní spektrometrie metody MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- albendazol MeSH
- anthelmintika MeSH
- benzimidazoly MeSH
- fenbendazol MeSH
- flubendazole MeSH Prohlížeč
- mebendazol MeSH
Benzimidazoles anthelmintics, which enter into environment primarily through excretion in the feces or urine of treated animals, can affect various organisms and disrupt ecosystem balance. The present study was designed to test the phytotoxicity and biotransformation of the three benzimidazole anthelmintics albendazole (ABZ), fenbendazole (FBZ) and flubendazole (FLU) in the harebell (Campanula rotundifolia). This meadow plant commonly grows in pastures and comes into contact with anthelmintics through the excrements of treated animals. Suspensions of harebell cells in culture medium were used as an in vitro model system. ABZ, FLU and FBZ were not found to be toxic for harebell cells, which were able to metabolize ABZ, FLU and FBZ via the formation of a wide scale of metabolites. Ultrahigh-performance liquid chromatography coupled with high mass accuracy tandem mass spectrometry (UHPLC-MS/MS) led to the identification of 24, 18 and 29 metabolites of ABZ, FLU and FBZ, respectively. Several novel metabolites were identified for the first time. Based on the obtained results, the schemes of the metabolic pathways of these anthelmintics were proposed. Most of these metabolites can be considered deactivation products, but a substantial portion of them may readily be decomposed to biologically active substances which could negatively affect ecosystems.
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