A New Route of Fucoidan Immobilization on Low Density Polyethylene and Its Blood Compatibility and Anticoagulation Activity
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Odkazy
PubMed
27294915
PubMed Central
PMC4926442
DOI
10.3390/ijms17060908
PII: ijms17060908
Knihovny.cz E-zdroje
- Klíčová slova
- anticoagulant, biomaterials, fucoidan, heparin, plasma treatment, thrombosis,
- MeSH
- antikoagulancia škodlivé účinky chemie farmakologie MeSH
- heparin škodlivé účinky chemie farmakologie MeSH
- krev účinky léků MeSH
- lidé MeSH
- polyethylen chemie MeSH
- polysacharidy škodlivé účinky chemie farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antikoagulancia MeSH
- fucoidan MeSH Prohlížeč
- heparin MeSH
- polyethylen MeSH
- polysacharidy MeSH
Beside biomaterials' bulk properties, their surface properties are equally important to control interfacial biocompatibility. However, due to the inadequate interaction with tissue, they may cause foreign body reaction. Moreover, surface induced thrombosis can occur when biomaterials are used for blood containing applications. Surface modification of the biomaterials can bring enhanced surface properties in biomedical applications. Sulfated polysaccharide coatings can be used to avoid surface induced thrombosis which may cause vascular occlusion (blocking the blood flow by blood clot), which results in serious health problems. Naturally occurring heparin is one of the sulfated polysaccharides most commonly used as an anticoagulant, but its long term usage causes hemorrhage. Marine sourced sulfated polysaccharide fucoidan is an alternative anticoagulant without the hemorrhage drawback. Heparin and fucoidan immobilization onto a low density polyethylene surface after functionalization by plasma has been studied. Surface energy was demonstrated by water contact angle test and chemical characterizations were carried out by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Surface morphology was monitored by scanning electron microscope and atomic force microscope. Finally, their anticoagulation activity was examined for prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin time (TT).
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