Antifungal effects of the biological agent Pythium oligandrum observed in vitro
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
PubMed
27418287
PubMed Central
PMC11104119
DOI
10.1177/1098612x16658690
PII: 1098612X16658690
Knihovny.cz E-resources
- MeSH
- Antifungal Agents pharmacology MeSH
- Cats MeSH
- Microsporum drug effects MeSH
- Cat Diseases drug therapy microbiology MeSH
- Parasitic Sensitivity Tests veterinary MeSH
- Pythium * MeSH
- Tinea drug therapy microbiology veterinary MeSH
- Trichophyton drug effects MeSH
- Hair microbiology MeSH
- Treatment Outcome MeSH
- Animals MeSH
- Check Tag
- Cats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antifungal Agents MeSH
Objectives Dermatophytosis, commonly known as ringworm, is a superficial fungal skin disease and zoonosis. Pythium oligandrum is a micromycete with mycoparasitic properties that is used in agriculture to control fungal infections on plants. Formulations containing P oligandrum were also developed for the treatment of dermatophytoses, but only a small number of case studies have been published. In order to document the process in simplified conditions in vitro, we investigated the effectiveness of P oligandrum against three pathogenic dermatophytes common in domestic animals. Methods Cultures of the pathogens grown on nutrient media and experimentally infected cat hair were treated with P oligandrum preparations in therapeutic concentration and the changes were documented by microscopic videos and scanning electron microscopy. Results There was strong mycoparasitic activity of P oligandrum against Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes. Conclusions and relevance P oligandrum was demonstrated to be effective against three common causes of dermatophytosis in vitro.
Institute of Geology Academy of Sciences Prague Czech Republic
Private Veterinary Practice for Small Animals Prague Czech Republic
Sevaron Diagnostic Laboratory Brno Czech Republic
Vemodia Laboratory for Veterinary Molecular Diagnostics Prague Czech Republic
See more in PubMed
Moriello K, DeBoer DJ. Dermatophytosis. In: Greene DE. (ed). Infectious diseases of the dog and cat. 4th ed. St Louis, MO: Elsevier Saunders, 2012, pp 599–601.
Brožová J. Exploitation of the mycoparasitic fungus Pythium oligandrum in plant protection. Plant Prot Sci 2002; 38: 29–35.
Veselý D, Hejdánek S. Microbial relations of Pythium oligandrum and problems in the use of this organism for the biological control of damping-off in sugar-beet. Zbl Mikrobiol 1984; 139: 257–265.
Benhamou N, Rey P, Chérif M, et al.. Treatment with the mycoparasite Pythium oligandrum triggers induction of defense-related reactions in tomato roots when challenged with Fusarium oxysporum f sp radicis-lycopersici. Phytopathology 1997; 87: 108–122. PubMed
Masunaka A, Sekiguchi H, Takahashi H, et al.. Distribution and expression of elicitin-like protein genes of the biocontrol agent Pythium oligandrum. J Phytopathol 2010; 158: 417–426.
Van Der Plaats-Niterink AJ. Monograph of the genus Pythium. http://www.fungalbiodiversitycentre.com/publications/1021/content_files/content.htm (1981, January 15, 2016).
Laing SAK, Deacon JW. Video microscopical comparison of mycoparasitism by Pythium oligandrum, P. nunn and an unnamed Pythium species. Mycol Res 1991; 95: 469–479.
Skořepová M. Současné možnosti terapie onychomykóz [article in Czech]. Farmakoterapie 2007; 3: 249–251.
Načeradská M, Mencl K, Zálabská E. Léčba dermatofytózy pomocí Pythium oligandrum – kazuistika [article in Czech]. Veterinární lékař 2011; 1: 11–16.
Načeradská M, Mencl K. Biopreparát s Pythium oligandrum při léčbě dermatofytózy koček – kazuistiky [article in Czech]. Veterinářství 2010; 10: 559–563.
Vršková D. Zkušenosti s biologickou léčbou dermatofytózy morčat pomocí mikroorganismu Pythium oligandrum [article in Czech]. Veterinářství 2014; 64: 510–514.
Načeradská M, Fridrichová M, Lány P, et al.. Mycoparasitism of Pythium oligandrum observed against Microsporum canis in agar media and on hairs – in vitro observations [abstract]. J Feline Med Surg 2015; 17: 817. PubMed PMC
Deacon JW, Henry CM. Mycoparasitism by Pythium oligandrum and P. acanthicum. Soil Biol Biochem 1978; 10: 409–415.
Načeradská M, Lány P, Loučka M. Kontrola a terapie dermatofytóz u praktických veterinárních lékařů v České republice – retrospektivní studie [article in Czech]. Veterinářství 2013; 7: 508–511.
Davanlou M, Madsen AM, Madsen CH, et al.. Parasitism of macroconidia, chlamydospores and hyphae of Fusarium culmorum by mycoparasitic Pythium species. Plant Pathol 1999; 48: 352–359.
Antifungal effects of the biological agent Pythium oligandrum observed in vitro
