Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27469472
DOI
10.1016/j.jconrel.2016.07.036
PII: S0168-3659(16)30471-0
Knihovny.cz E-zdroje
- Klíčová slova
- drug delivery, electrospinning, mucoadhesive film, mucus penetrating nanoparticles, nanofibres, sublingual vaccines,
- MeSH
- adheziva chemie MeSH
- aplikace bukální MeSH
- aplikace sublinguální MeSH
- léčivé přípravky aplikace a dávkování MeSH
- lékové transportní systémy metody MeSH
- liposomy chemie MeSH
- lymfatické uzliny metabolismus MeSH
- myši MeSH
- nanočástice chemie MeSH
- nanovlákna chemie MeSH
- polyethylenglykoly chemie MeSH
- polyglactin 910 chemie MeSH
- prasata MeSH
- ústní sliznice metabolismus MeSH
- vakcinace metody MeSH
- vakcíny aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adheziva MeSH
- léčivé přípravky MeSH
- liposomy MeSH
- poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer MeSH Prohlížeč
- polyethylenglykoly MeSH
- polyglactin 910 MeSH
- vakcíny MeSH
Nanofibre-based mucoadhesive films were invented for oromucosal administration of nanocarriers used for delivery of drugs and vaccines. The mucoadhesive film consists of an electrospun nanofibrous reservoir layer, a mucoadhesive film layer and a protective backing layer. The mucoadhesive layer is responsible for tight adhesion of the whole system to the oral mucosa after application. The electrospun nanofibrous reservoir layer is intended to act as a reservoir for polymeric and lipid-based nanoparticles, liposomes, virosomes, virus-like particles, dendrimers and the like, plus macromolecular drugs, antigens and/or allergens. The extremely large surface area of nanofibrous reservoir layers allows high levels of nanoparticle loading. Nanoparticles can either be reversibly adsorbed to the surface of nanofibres or they can be deposited in the pores between the nanofibres. After mucosal application, nanofibrous reservoir layers are intended to promote prolonged release of nanoparticles into the submucosal tissue. Reversible adsorption of model nanoparticles as well as sufficient mucoadhesive properties were demonstrated. This novel system appears appropriate for the use in oral mucosa, especially for sublingual and buccal tissues. To prove this concept, trans-/intramucosal and lymph-node delivery of PLGA-PEG nanoparticles was demonstrated in a porcine model. This system can mainly be used for sublingual immunization and the development of "printed vaccine technology".
Department of Pharmacology and Immunotherapy Veterinary Research Institute Brno Czech Republic
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