Nrf2 as a key player of redox regulation in cardiovascular diseases
Language English Country Czech Republic Media print
Document type Journal Article, Review
PubMed
27643930
DOI
10.33549/physiolres.933403
PII: 933403
Knihovny.cz E-resources
- MeSH
- Antioxidant Response Elements * MeSH
- NF-E2-Related Factor 2 metabolism MeSH
- Cardiovascular Diseases metabolism MeSH
- Humans MeSH
- Oxidative Stress * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- NF-E2-Related Factor 2 MeSH
- NFE2L2 protein, human MeSH Browser
The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. Keap1-Nrf2-ARE system regulates a great set of detoxificant and antioxidant enzymes in cells after ROS and electrophiles exposure. In this review we focus on radical-generating systems in cardiovascular system as well as on Nrf2 as a target against oxidative stress and a key player of redox regulation in cardiovascular diseases. We also summarize the current knowledge about the role of Nrf2 in pathophysiology of several CVD (hypertension, cardiac hypertrophy, cardiomyopathies) as well as in cardioprotection against myocardial ischemia/ reperfusion injury.
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