The molecular basis of jaundice: An old symptom revisited
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
28004508
DOI
10.1111/liv.13351
Knihovny.cz E-zdroje
- Klíčová slova
- Gilbert syndrome, bilirubin, chronic diseases, human health, jaundice, oxidative stress,
- MeSH
- bilirubin metabolismus MeSH
- lidé MeSH
- sexuální faktory MeSH
- žloutenka etiologie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- bilirubin MeSH
Increased serum bilirubin level is a widely used diagnostic marker for hepatic illnesses. Nevertheless, mild elevation of unconjugated serum bilirubin (such as in Gilbert syndrome) has been recently demonstrated to correlate with low risk of chronic inflammatory and/or oxidative stress-mediated diseases. In accord, a low serum bilirubin level has emerged as an important predisposing factor or a biomarker of these pathologic conditions including cardiovascular, tumour, and possibly neurodegenerative diseases. Bilirubin possesses multiple biological actions with interaction in a complex network of enzymatic and signalling pathways. The fact that the liver is the main organ controlling the bioavailability of bilirubin emphasizes the central role of this organ in human health.
1st Faculty of Medicine Charles University Prague Czech Republic
Center for Liver Diseases Azienda Sanitaria Integrata Trieste Italy
Liver Research Center Italian Liver Foundation ONLUS AREA Science Park Trieste Italy
Citace poskytuje Crossref.org
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