Plasma Phospholipid Fatty Acid Profile is Altered in Both Septic and Non-Septic Critically Ill: A Correlation with Inflammatory Markers and Albumin
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
28039586
DOI
10.1007/s11745-016-4226-x
PII: 10.1007/s11745-016-4226-x
Knihovny.cz E-zdroje
- Klíčová slova
- Fatty acid profile, Inflammation, Lipoproteins, Oxidative stress, PUFA, Plasma lipids, Sepsis,
- MeSH
- biologické markery krev MeSH
- C-reaktivní protein metabolismus MeSH
- fosfolipidy krev MeSH
- interleukiny metabolismus MeSH
- kalcitonin metabolismus MeSH
- kritický stav * MeSH
- kyseliny mastné mononenasycené krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- mastné kyseliny krev MeSH
- prospektivní studie MeSH
- senioři MeSH
- sepse imunologie metabolismus MeSH
- studie případů a kontrol MeSH
- syndrom systémové zánětlivé reakce imunologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- biologické markery MeSH
- C-reaktivní protein MeSH
- fosfolipidy MeSH
- interleukiny MeSH
- kalcitonin MeSH
- kyseliny mastné mononenasycené MeSH
- mastné kyseliny MeSH
This study analyzes fatty acid (FA) composition in plasma lipids and erythrocyte phospholipids while comparing septic and non-septic critically ill patients. The aim was to describe impacts of infection and the inflammatory process. Patients with severe sepsis (SP, n = 13); age-, sex- and APACHE II score-matched non-septic critically ill with systemic inflammatory response syndrome (NSP, n = 13); and age-/sex-matched healthy controls (HC, n = 13) were included in a prospective case-control study during the first 24 h after admission to the intensive care unit. In both SP and NSP, lower n-6 polyunsaturated FA (PUFA) accompanied by higher proportions of monounsaturated FA (MUFA) in plasma phospholipids (PPL) was observed relative to HC. MUFA proportion was negatively correlated with n-6 PUFA, high density lipoprotein cholesterol (HDL-C), and albumin. MUFA was positively correlated with C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL-6, IL-10), oxidized low density lipoproteins (ox-LDL), and conjugated dienes (CD). In both SP and NSP, inflammatory and lipid peroxidation markers were significantly higher-CRP (p < 0.001; p = 0.08), IL-6, IL-10, TNF-α (p < 0.01, p = 0.06), ox-LDL, and CD while total cholesterol, HDL-C, LDL-C albumin, and 20:4n-6/22:6n-3 and n-6/n-3 ratios were lower compared to HC. In conclusion, the changes in plasma lipid FA profile relate to the intensity of inflammatory and peroxidative response regardless of insult etiology. The lower MUFA and higher n-6 PUFA proportions in PPL were inversely correlated with cholesterol and albumin levels.
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