Decreased paraoxonase activity in critically ill patients with sepsis

. 2010 Mar ; 10 (1) : 21-5. [epub] 20090904

Jazyk angličtina Země Itálie Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid19760042

Paraoxonase 1 is believed to play a role in preventing lipid oxidation and, thus, limiting production of proinflammatory mediators. Systemic inflammatory response in sepsis increases oxidative stress and decreases high-density lipoprotein (HDL) concentrations. The objective of this study was to investigate serum paraoxonase 1 activities in critically ill patients with sepsis and after recovery. Serum paraoxonase 1 arylesterase/paraoxonase activities, concentration of total cholesterol, HDL cholesterol (HDL-C) and serum C-reactive protein (CRP) in septic patients of a medical intensive care unit (n = 30) and age/sex-matched outpatient controls without sepsis (n = 30) were analyzed. Paired convalescent samples were also taken 1 week after recovery (n = 11). In septic patients, both arylesterase (88.3 +/- 36.5 vs. 162.1 +/- 44.8 kU/l, P < 0.001) and paraoxonase (75.2 +/- 50.0 vs. 125.2 +/- 69.4 U/l, P < 0.01) paraoxonase 1 activities decreased as compared to controls. Both activities normalized after recovery. Negative correlation was found between CRP and both arylesterase (r = -0.676, P < 0.001) and paraoxonase (r = -0.401, P < 0.01) as well as positive correlation between HDL-C and both arylesterase (r = 0.585, P < 0.001) and paraoxonase (r = 0.405, P < 0.01) paraoxonase 1 activities. The decreased activity of paraoxonase 1 in negative correlation with CRP offers a potentially useful marker of sepsis progress and recovery in critically ill patients.

Zobrazit více v PubMed

Am J Hum Genet. 1983 Nov;35(6):1126-38 PubMed

Crit Care Med. 2003 May;31(5):1359-66 PubMed

Atherosclerosis. 2007 Sep;194(1):175-81 PubMed

Scand J Immunol. 1998 Oct;48(4):419-24 PubMed

Inflamm Bowel Dis. 2009 Jan;15(1):93-9 PubMed

Atherosclerosis. 1998 Aug;139(2):307-15 PubMed

Crit Care Med. 1985 Oct;13(10):818-29 PubMed

Crit Care Clin. 2000 Apr;16(2):179-92 PubMed

Clin Chem. 1986 Jan;32(1 Pt 1):142-5 PubMed

Shock. 2003 Sep;20(3):208-12 PubMed

J Clin Invest. 1995 Dec;96(6):2758-67 PubMed

Atherosclerosis. 2006 Jun;186(2):396-401 PubMed

Atherosclerosis. 2008 Jan;196(1):270-274 PubMed

Free Radic Biol Med. 2004 Dec 15;37(12):1986-94 PubMed

Clin Chem. 1986 Apr;32(4):671-3 PubMed

J Clin Invest. 1995 Dec;96(6):2882-91 PubMed

Shock. 2004 Mar;21(3):210-21 PubMed

Biochemistry. 2005 Sep 6;44(35):11843-54 PubMed

J Nephrol. 2004 Nov-Dec;17(6):813-8 PubMed

J Lipid Res. 2005 Mar;46(3):389-403 PubMed

EMBO J. 1989 Dec 1;8(12):3773-9 PubMed

Chest. 1992 Jun;101(6):1644-55 PubMed

Najít záznam

Citační ukazatele

Nahrávání dat ...

    Možnosti archivace