Andrographolide: antibacterial activity against common bacteria of human health concern and possible mechanism of action
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28097636
DOI
10.1007/s12223-017-0496-9
PII: 10.1007/s12223-017-0496-9
Knihovny.cz E-zdroje
- Klíčová slova
- Andrographolide, Antimicrobial, Bacteriostatic, Biofilm, DNA synthesis,
- MeSH
- Andrographis chemie MeSH
- antibakteriální látky farmakologie MeSH
- biofilmy účinky léků MeSH
- biosyntetické dráhy účinky léků MeSH
- diterpeny izolace a purifikace farmakologie MeSH
- DNA biosyntéza MeSH
- grampozitivní bakterie účinky léků fyziologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- mikrobiální viabilita účinky léků MeSH
- rostlinné extrakty izolace a purifikace farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- andrographolide MeSH Prohlížeč
- antibakteriální látky MeSH
- diterpeny MeSH
- DNA MeSH
- rostlinné extrakty MeSH
Increasing bacterial resistance to common drugs is a major public health concern for the treatment of infectious diseases. Certain naturally occurring compounds of plant sources have long been reported to possess potential antimicrobial activity. This study was aimed to investigate the antibacterial activity and possible mechanism of action of andrographolide (Andro), a diterpenoid lactone from a traditional medicinal herb Andrographis paniculata. Extent of antibacterial action was assessed by minimal bactericidal concentration method. Radiolabeled N-acetyl glucosamine, leucine, thymidine, and uridine were used to determine the effect of Andro on the biosyntheses of cell wall, protein, DNA, and RNA, respectively. In addition, anti-biofilm potential of this compound was also tested. Andro showed potential antibacterial activity against most of the tested Gram-positive bacteria. Among those, Staphylococcus aureus was found to be most sensitive with a minimal inhibitory concentration value of 100 μg/mL. It was found to be bacteriostatic. Specific inhibition of intracellular DNA biosynthesis was observed in a dose-dependent manner in S. aureus. Andro mediated inhibition of biofilm formation by S. aureus was also found. Considering its antimicrobial potency, Andro might be accounted as a promising lead for new antibacterial drug development.
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