Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis
Language English Country United Arab Emirates Media print
Document type Journal Article, Review
PubMed
28201972
DOI
10.2174/1381612823666170214120708
PII: CPD-EPUB-81769
Knihovny.cz E-resources
- Keywords
- Cell-based tolerogenic therapy, multiple sclerosis, regulatory T cells, rheumatoid arthritis, tolerogenic dendritic cells, type 1 diabetes,
- MeSH
- Autoimmunity drug effects immunology MeSH
- Cell- and Tissue-Based Therapy methods MeSH
- Diabetes Mellitus, Type 1 immunology therapy MeSH
- Immune Tolerance drug effects immunology MeSH
- Immunosuppressive Agents administration & dosage MeSH
- Humans MeSH
- Disease Models, Animal * MeSH
- Organic Chemicals administration & dosage MeSH
- T-Lymphocytes, Regulatory drug effects immunology MeSH
- Arthritis, Rheumatoid immunology therapy MeSH
- Multiple Sclerosis immunology therapy MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Immunosuppressive Agents MeSH
- Organic Chemicals MeSH
- Tolerogen MeSH Browser
Cell-based tolerogenic therapy is a promising approach for the treatment of autoimmune diseases and transplant rejection. Regulatory T cells and tolerogenic dendritic cells have been particularly explored in the treatment of various autoimmune disorders in experimental models of disease. Although some of these cells have already been tested in a limited number of clinical trials, there is still a need for preclinical research on tolerogenic cells in animal models of autoimmunity. This review will focus on the relevance of data obtained from studies in experimental animal models for the use of tolerogenic cell-based therapy in humans. Also, perspectives for further improvement of tolerogenic cell preparation towards enhanced suppressive activity and stability of the cells will be discussed.
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