Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28336346
DOI
10.1016/j.antiviral.2017.03.012
PII: S0166-3542(17)30024-4
Knihovny.cz E-zdroje
- Klíčová slova
- Adenosine analogue, Antiviral activity, BCX4430, Cytotoxicity, Flavivirus, Nucleoside inhibitor,
- MeSH
- adenin analogy a deriváty MeSH
- adenosin analogy a deriváty farmakologie MeSH
- antivirové látky farmakologie MeSH
- buněčné linie MeSH
- Cercopithecus aethiops MeSH
- Culicidae virologie MeSH
- Flavivirus účinky léků MeSH
- klíšťata virologie MeSH
- klíšťová encefalitida přenos virologie MeSH
- nemoci přenášené klíšťaty MeSH
- prasata MeSH
- purinové nukleosidy antagonisté a inhibitory chemie MeSH
- pyrrolidiny MeSH
- replikace viru účinky léků MeSH
- Vero buňky MeSH
- viabilita buněk účinky léků MeSH
- virus západního Nilu účinky léků patogenita MeSH
- viry klíšťové encefalitidy účinky léků patogenita MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adenin MeSH
- adenosin MeSH
- antivirové látky MeSH
- galidesivir MeSH Prohlížeč
- purinové nukleosidy MeSH
- pyrrolidiny MeSH
There are currently no approved antiviral therapies against medically important human flaviviruses. The imino-C-nucleoside BCX4430 shows broad-spectrum antiviral activity against a wide range of RNA viruses. Here, we demonstrate that BCX4430 inhibits tick-borne species of the genus Flavivirus; however, the antiviral effect varies against individual species. Micro-molar BCX4430 levels inhibited tick-borne encephalitis virus (TBEV); while, approximately 3-8-fold higher concentrations were needed to inhibit louping ill virus and Kyasanur Forest disease virus. Moreover, the compound strongly inhibited in vitro replication of West Nile virus, a typical mosquito-transmitted flavivirus. Two chemical forms of the compound, i.e. BCX4430 and BCX4430 hydrochloride, were compared and both exerted similar inhibitory profiles in our in vitro antiviral assay systems and no or negligible cytotoxicity in porcine kidney stable and Vero cells. The obtained data indicate that, in addition to mosquito-borne flaviviruses, the compound has strong antiviral activity against members of the TBEV serocomplex.
Department of Virology Veterinary Research Institute Hudcova 70 CZ 62100 Brno Czech Republic
Rega Institute for Medical Research KU Leuven Minderbroedersstraat 10 B 3000 Leuven Belgium
Citace poskytuje Crossref.org
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