GABA spectra and remote distractor effect in progressive supranuclear palsy: A pilot study
Language English Country France Media print-electronic
Document type Journal Article
PubMed
28385472
DOI
10.1016/j.neurol.2017.03.007
PII: S0035-3787(16)30139-4
Knihovny.cz E-resources
- Keywords
- Distraction, Eye movements, GABA, Magnetic resonance, Progressive supranuclear palsy, Spectroscopy,
- MeSH
- gamma-Aminobutyric Acid metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Magnetic Resonance Imaging MeSH
- Oculomotor Muscles diagnostic imaging physiopathology MeSH
- Pilot Projects MeSH
- Eye Movements MeSH
- Prefrontal Cortex diagnostic imaging metabolism MeSH
- Supranuclear Palsy, Progressive diagnostic imaging metabolism psychology MeSH
- Saccades MeSH
- Aged MeSH
- Photic Stimulation MeSH
- Healthy Volunteers MeSH
- Visual Fields MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- gamma-Aminobutyric Acid MeSH
Disturbances of the gamma-aminobutyric-acid (GABA) system have been suspected of contributing to the pathophysiology of progressive supranuclear palsy (PSP). The ability to rapidly resolve competitive action decisions, such as shifting the gaze to one particular stimulus rather than another, can be predicted by the concentration of GABA in the region of the frontal cortex relevant to eye movements. For this reason, our study measured GABA levels in seven PSP patients and eight healthy controls, using proton magnetic resonance spectroscopy, and assessed the relationship of these measurements to the remote distractor effect (RDE), an eye-movement paradigm investigating competitive action decisions. No significant differences were found in either frontal-eye-field GABA levels or RDE between PSP patients and controls.
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