Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours
Language English Country Denmark Media print-electronic
Document type Comparative Study, Journal Article
PubMed
28393404
DOI
10.1111/jop.12579
Knihovny.cz E-resources
- Keywords
- c-MYC, radiotherapy, squamous cell carcinoma, tongue,
- MeSH
- Squamous Cell Carcinoma of Head and Neck MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Survival Rate MeSH
- Young Adult MeSH
- Head and Neck Neoplasms genetics metabolism mortality MeSH
- Tongue Neoplasms genetics metabolism mortality MeSH
- Proto-Oncogene Proteins c-myc biosynthesis genetics MeSH
- Gene Expression Regulation, Neoplastic * MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Carcinoma, Squamous Cell genetics metabolism mortality MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- MYC protein, human MeSH Browser
- Proto-Oncogene Proteins c-myc MeSH
BACKGROUND: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. METHODS: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. RESULTS: All 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. CONCLUSIONS: The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.
Department of Clinical and Experimental Medicine University of Foggia Foggia Italy
Department of Clinical Sciences ENT Umeå University Umeå Sweden
Department of Medical Biosciences Pathology Umeå University Umeå Sweden
Institut de Génétique Moléculaire Hôpital St Louis Université Paris 7 Paris France
RECAMO Masaryk Memorial Cancer Institute Brno Czech Republic
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