Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články
- Klíčová slova
- Omentin-1, PPROM, Val109Asp polymorphism, adipokine, preterm birth,
- MeSH
- cytokiny krev MeSH
- dospělí MeSH
- ELISA MeSH
- GPI-vázané proteiny krev MeSH
- kohortové studie MeSH
- lektiny krev MeSH
- lidé MeSH
- neparametrická statistika MeSH
- novorozenec MeSH
- polymorfismus genetický MeSH
- porod v termínu * MeSH
- předčasný odtok plodové vody krev genetika MeSH
- předčasný porod krev genetika MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- cytokiny MeSH
- GPI-vázané proteiny MeSH
- ITLN1 protein, human MeSH Prohlížeč
- lektiny MeSH
OBJECTIVE: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs). MATERIALS AND METHODS: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n = 16) and without (n = 14) preterm premature rupture of membranes (PPROM). RESULTS: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p = .015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p = .990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established. CONCLUSIONS: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
b Research Centre for the Toxic Compounds in the Environment Brno Czech Republic
c Department of Obstetrics and Gynaecology University Hospital Brno Brno Czech Republic
Department of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic
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