Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

1st Faculty of Medicine Institute of Hygiene and Epidemiology Charles University 128 00 Prague 2 Czech Republic

2nd Faculty of Medicine Institute of Public Health and Preventive Medicine Charles University 150 06 Prague 5 Czech Republic

American Cancer Society Atlanta Georgia 30303 USA

Brigham and Women's Hospital and VA Boston Boston Massachusetts 02115 USA

Cancer Epidemiology Centre Cancer Council Victoria Melbourne Victoria 3004 Australia

Cancer Prevention Program Fred Hutchinson Cancer Research Center Seattle Washington 98109 USA

Carol Davila University of Medicine and Pharmacy Th Burghele Hospital 050659 Bucharest Romania

Center 'Bioengineering' of the Russian Academy of Sciences Moscow 117312 Russia

Centre de Recherche en Épidémiologie et Santé des Populations Université Paris Saclay UPS UVSQ Gustave Roussy 94805 Villejuif France

Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Carlton Victoria 3053 Australia

Centre National de Genotypage Institut de Genomique Commissariat à l'Energie Atomique et aux Energies Alternatives 91057 Evry France

CeRePP Tenon Hospital 75020 Paris France

Clinical Center of Serbia Clinic of Urology University of Belgrade Faculty of Medicine 11000 Belgrade Serbia

College of Human Medicine Michigan State University Grand Rapids Michigan 49503 USA

Dana Farber Cancer Institute Boston Massachusetts 02215 USA

Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute 656 53 Brno Czech Republic

Department of Community Medicine Faculty of Health Sciences University of Tromsø The Arctic University of Norway 9037 Tromsø Norway

Department of Computational Biology St Jude Children's Research Hospital Memphis Tennessee 38105 USA

Department of Epidemiology and Biostatistics School of Public Health Indiana University Bloomington Bloomington Indiana 47405 USA

Department of Epidemiology Division of Cancer Prevention and Population Sciences The University of Texas MD Anderson Cancer Center Houston Texas 77230 USA

Department of Epidemiology German Institute of Human Nutrition Potsdam Rehbrücke 14558 Nuthetal Germany

Department of Epidemiology Institute of Occupational Medicine 91 348 Lodz Poland

Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York 10029 USA

Department of Health National Institute for Health and Welfare 00271 Helsinki Finland

Department of Health Sciences Research Mayo Clinic Jacksonville Florida 32224 USA

Department of Health Sciences Research Mayo Clinic Rochester Minnesota 55905 USA

Department of Medical Epidemiology and Biostatistics Karolinska Institutet 171 77 Stockholm Sweden

Department of Medicine The University of Melbourne Melbourne Victoria 3010 Australia

Department of Oncology Cambridge University Hospitals NHS Foundation Trust Cambridge CB2 0QQ UK

Department of Oncology University of Cambridge Cambridge CB1 8RN UK

Department of Preventive Medicine Faculty of Medicine Palacky University 775 15 Olomouc Czech Republic

Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology Trondheim 7491 Norway

Department of Public Health and Primary Care University of Cambridge Cambridge CB2 0QQ UK

Department of Research Cancer Registry of Norway Institute of Population Based Cancer Research 0304 Oslo Norway

Department of Surgical and Perioperative Sciences Urology and Andrology Umeå University 901 85 Umeå Sweden

Department of Urology Mayo Medical School and Mayo Clinic Rochester Minnesota 55902 USA

Department of Urology The University of Texas M D Anderson Cancer Center Houston Texas 77030 USA

Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department Health and Human Services Bethesda Maryland 20892 USA

Division of Genetics and Epidemiology The Institute of Cancer Research London SW7 3RP UK

Division of Molecular Pathology The Institute of Cancer Research London SW7 3RP UK

Division of Urology Spectrum Health Grand Rapids Michigan 49503 USA

Fondation Jean Dausset Centre d'Etude du Polymorphisme Humain 75010 Paris France

Genetic Epidemiology Group Folkhälsan Research Center 00250 Helsinki Finland

Genetic Medicine and Family Cancer Clinic Royal Melbourne Hospital Parkville Victoria 3050 Australia

Harvard T H Chan School of Public Health Boston Massachusetts 02115 USA

Human Genetics Foundation 10126 Torino Italy

HUNT Research Centre Department of Public Health and General Practice Norwegian University of Science and Technology Levanger 7600 Norway

Institute of Environmental Medicine Karolinska Institutet 171 77 Stockholm Sweden

Institute of Pathology School of Medicine University of Belgrade 11000 Belgrade Serbia

International Agency for Research on Cancer 69008 Lyon France

International Hereditary Cancer Center Department of Genetics and Pathology Pomeranian Medical University 70 204 Szczecin Poland

Kurchatov Scientific Center Moscow 123182 Russia

Leeds Institute of Cancer and Pathology University of Leeds Cancer Research Building St James's University Hospital Leeds LS9 7TF UK

London School of Hygiene and Tropical Medicine University of London London WC1H 9SH UK

McGill University and Genome Quebec Innovation Centre Montreal Quebec Canada H3A 0G1

Medical Oncology Royal Marsden NHS Foundation Trust London SW3 6JJ UK

National Institute of Public Health 050463 Bucharest Romania

National Public Health Center National Directorate of Environmental Health 1097 Budapest Hungary

QIMR Berghofer Medical Research Institute Herston Queensland 4006 Australia

Regional Authority of Public Health in Banska Bystrica 975 56 Banska Bystrica Slovakia

Russian N N Blokhin Cancer Research Centre Moscow 115478 Russian Federation

School of Public Health The University of Queensland Brisbane Queensland 4072 Australia

The M Sklodowska Curie Cancer Center and Institute of Oncology 02 034 Warsaw Poland

Université Paris Diderot INSERM Unité Variabilité Génétique et Maladies Humaines 75010 Paris France

UPMC Univ Paris 06 GRC n°5 75013 Paris France

Van Andel Research Institute Center for Cancer Genomics and Quantitative Biology Grand Rapids Michigan 49503 USA

Vanderbilt Ingram Cancer Center Department of Urology Vanderbilt University Medical Center Nashville Tennessee 37232 USA

Vanderbilt Ingram Cancer Center Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville Tennessee 37209 USA

Vanderbilt Ingram Cancer Center Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt University Medical Center Nashville Tennessee 37203 USA

Warren Alpert Medical School of Brown University Providence Rhode Island 02903 USA

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