Mitochondrial dysfunction and potential anticancer therapy
Language English Country United States Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
28682452
DOI
10.1002/med.21459
Knihovny.cz E-resources
- Keywords
- antibiotics, autophagy, cancer, cancer stem cells, mitochondria, mitochondrial dysfunction, mitophagy,
- MeSH
- Humans MeSH
- Mitochondria metabolism pathology MeSH
- Neoplasms metabolism pathology therapy MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.
Institute of Molecular Biology and Biophysics Novosibirsk Russia
International Clinical Research Center and St Anne's University Hospital Brno Czech Republic
Novosibirsk State University Pirogova Novosibirsk Russia
Oncology Program Vall D'Hebron Research Institute Barcelona Spain
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