Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.

Institute of Molecular Biology and Biophysics Novosibirsk Russia

International Clinical Research Center and St Anne's University Hospital Brno Czech Republic

Novosibirsk State University Pirogova Novosibirsk Russia

Oncology Program Vall D'Hebron Research Institute Barcelona Spain

Thomas Steitz Laboratory Department of Molecular Biophysics and Biochemistry Center for Structural Biology Howard Hughes Medical Institute Yale University New Haven Connecticut

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