Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28745813
DOI
10.1111/cmi.12769
Knihovny.cz E-zdroje
- MeSH
- adaptorové proteiny signální transdukční genetika MeSH
- adaptorové proteiny vezikulární transportní genetika MeSH
- faktor 3 asociovaný s receptory TNF metabolismus MeSH
- faktor 6 asociovaný s receptory TNF metabolismus MeSH
- Francisella tularensis imunologie patogenita MeSH
- imunitní únik imunologie MeSH
- myši inbrední C57BL MeSH
- myši knockoutované MeSH
- myši MeSH
- přirozená imunita imunologie MeSH
- protein MyD88 genetika MeSH
- receptory rozpoznávající vzory antagonisté a inhibitory MeSH
- sekreční systém typu VI metabolismus MeSH
- tularemie imunologie mikrobiologie patologie MeSH
- ubikvitinace imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adaptorové proteiny signální transdukční MeSH
- adaptorové proteiny vezikulární transportní MeSH
- faktor 3 asociovaný s receptory TNF MeSH
- faktor 6 asociovaný s receptory TNF MeSH
- IPS-1 protein, mouse MeSH Prohlížeč
- Myd88 protein, mouse MeSH Prohlížeč
- protein MyD88 MeSH
- receptory rozpoznávající vzory MeSH
- sekreční systém typu VI MeSH
- TICAM-1 protein, mouse MeSH Prohlížeč
The success of pathogens depends on their ability to circumvent immune defences. Francisella tularensis is one of the most infectious bacteria known. The remarkable virulence of Francisella is believed to be due to its capacity to evade or subvert the immune system, but how remains obscure. Here, we show that Francisella triggers but concomitantly inhibits the Toll-like receptor, RIG-I-like receptor, and cytoplasmic DNA pathways. Francisella subverts these pathways at least in part by inhibiting K63-linked polyubiquitination and assembly of TRAF6 and TRAF3 complexes that control the transcriptional responses of pattern recognition receptors. We show that this mode of inhibition requires a functional type VI secretion system and/or the presence of live bacteria in the cytoplasm. The ability of Francisella to enter the cytosol while simultaneously inhibiting multiple pattern recognition receptor pathways may account for the notable capacity of this bacterium to invade and proliferate in the host without evoking a self-limiting innate immune response.
Citace poskytuje Crossref.org
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