Treatment of infectious diseases remains one of the principal research target for many researchers and healthcare providers worldwide. Herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2) are common human pathogens with an estimated 60-95% of the adult population infected by at least one of them. The worldwide disease burden of HSV is substantial, and acyclovir and related nucleoside analogues (viral DNA polymerase inhibitors) as therapies have led to significantly increased treatment efficacy of HSV infections. Although the treatment of HSV infection has greatly advanced through the use of nucleoside analogues therapy, the treatment efficacy has decreased significantly. This is due to the extensive use of nucleoside analogues drugs, which has created drug resistance, associated with other adverse effects as well. In this review, we aim to shed light on the HSV infection, the current pharmacologic treatment, and the use of dietary measures as alternative therapy option.Key words: HSV infection dietary measures antiviral drugs nucleoside analogues natural compounds.

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers

Nutraceutical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways

Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development