Transition dipole coupling modeling of optical activity enhancements in macromolecular protein systems
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29083053
DOI
10.1002/chir.22778
Knihovny.cz E-zdroje
- Klíčová slova
- Raman optical activity, circular dichroism, enhancement of optical activity, protein spectra, transition dipole coupling,
- MeSH
- molekulární modely MeSH
- multiproteinové komplexy chemie MeSH
- optická otáčivost * MeSH
- stereoizomerie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- multiproteinové komplexy MeSH
The transition dipole coupling model allows to vary systematically many parameters, such as chromophore geometries and transition dipoles. We used it to explore conditions favorable to chirality enhancement observed in many experiments on protein amyloidal precipitates. Stacking of β-sheet planes has been identified as a particularly powerful mechanism of the enhancement.
Institute of Organic Chemistry and Biochemistry Academy of Sciences Prague Czech Republic
University of Chemistry and Technology Prague Czech Republic
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