Transition dipole coupling modeling of optical activity enhancements in macromolecular protein systems
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
29083053
DOI
10.1002/chir.22778
Knihovny.cz E-resources
- Keywords
- Raman optical activity, circular dichroism, enhancement of optical activity, protein spectra, transition dipole coupling,
- MeSH
- Models, Molecular MeSH
- Multiprotein Complexes chemistry MeSH
- Optical Rotation * MeSH
- Stereoisomerism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Multiprotein Complexes MeSH
The transition dipole coupling model allows to vary systematically many parameters, such as chromophore geometries and transition dipoles. We used it to explore conditions favorable to chirality enhancement observed in many experiments on protein amyloidal precipitates. Stacking of β-sheet planes has been identified as a particularly powerful mechanism of the enhancement.
Institute of Organic Chemistry and Biochemistry Academy of Sciences Prague Czech Republic
University of Chemistry and Technology Prague Czech Republic
References provided by Crossref.org
