Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A. nidulans
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
Grantová podpora
00064203
Project of Ministry of Health of the Czech Republic for conceptual development of research organization (University Hospital Motol, Prague, Czech Republic)
CZ.1.05/1.1.00/02.0109
Project BIOCEV provided by the Ministry of Education, Youth and Sports of CR and ERDF
PubMed
29128933
DOI
10.1007/s11046-017-0223-8
PII: 10.1007/s11046-017-0223-8
Knihovny.cz E-zdroje
- Klíčová slova
- Aspergillus quadrilineatus, Aspergillus section Nidulantes, Haematopoietic stem cell transplant, Invasive aspergillosis,
- MeSH
- antifungální látky aplikace a dávkování MeSH
- Aspergillus klasifikace cytologie genetika izolace a purifikace MeSH
- chronická lymfatická leukemie komplikace MeSH
- cytomegalovirové infekce komplikace diagnóza MeSH
- DNA fungální chemie genetika MeSH
- fatální výsledek MeSH
- fylogeneze MeSH
- invazivní plicní aspergilóza diagnóza farmakoterapie mikrobiologie patologie MeSH
- kalmodulin genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mezerníky ribozomální DNA chemie genetika MeSH
- mikrobiální testy citlivosti MeSH
- mikroskopie elektronová rastrovací MeSH
- nemoc štěpu proti hostiteli komplikace diagnóza MeSH
- příjemce transplantátu MeSH
- sekvenční analýza DNA MeSH
- shluková analýza MeSH
- transplantace hematopoetických kmenových buněk škodlivé účinky MeSH
- tubulin genetika MeSH
- virová hepatitida u lidí komplikace diagnóza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- antifungální látky MeSH
- DNA fungální MeSH
- kalmodulin MeSH
- mezerníky ribozomální DNA MeSH
- tubulin MeSH
Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and β-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.
Department of Botany Faculty of Science Charles University Benátská 2 128 01 Prague 2 Czech Republic
Institute of Haematology and Blood Transfusion Prague Czech Republic
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