Antibiofilm activity of bioactive hop compounds humulone, lupulone and xanthohumol toward susceptible and resistant staphylococci
Jazyk angličtina Země Francie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29407045
DOI
10.1016/j.resmic.2017.12.005
PII: S0923-2508(18)30007-X
Knihovny.cz E-zdroje
- Klíčová slova
- Biofilms, Humulus, Staphylococcus,
- MeSH
- antibakteriální látky farmakologie MeSH
- biofilmy účinky léků MeSH
- buněčné linie MeSH
- cyklohexeny farmakologie MeSH
- flavonoidy farmakologie MeSH
- Humulus chemie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- propiofenony farmakologie MeSH
- rostlinné extrakty farmakologie MeSH
- Staphylococcus účinky léků genetika růst a vývoj MeSH
- terpeny farmakologie MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky MeSH
- cyklohexeny MeSH
- flavonoidy MeSH
- humulon MeSH Prohlížeč
- lupulon MeSH Prohlížeč
- propiofenony MeSH
- rostlinné extrakty MeSH
- terpeny MeSH
- xanthohumol MeSH Prohlížeč
Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials, and staphylococci are recognized as the most frequent cause of biofilm-associated infections. The hop plant (Humulus lupulus L.) contains substances that have been determined to act as anti-infective agents against bacteria, mainly in planktonic form. Therefore, we decided to investigate the antibiofilm properties of H. lupulus L.-derived compounds (humulone, lupulone and xanthohumol) against a selected group of Staphylococcus spp., including methicillin-susceptible and resistant strains. All tested hop compounds were shown to possess antimicrobial properties against all tested staphylococci, both planktonic and biofilm-dwelling, with no significant difference between resistant and susceptible strains. All compounds lowered the number of bacterial cells released from the biofilm, with the strongest effect seen for lupulone, followed by xanthohumol. Moreover, lupulone and xanthohumol were not only able to penetrate the biofilm and reduce the number of bacteria within it, but their higher concentrations (∼60 μg/mL for xanthohumol and ∼125 μg/mL for lupulone) reduced the number of surviving bacterial cells to zero.
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