Antibiofilm activity of bioactive hop compounds humulone, lupulone and xanthohumol toward susceptible and resistant staphylococci
Language English Country France Media print-electronic
Document type Journal Article
PubMed
29407045
DOI
10.1016/j.resmic.2017.12.005
PII: S0923-2508(18)30007-X
Knihovny.cz E-resources
- Keywords
- Biofilms, Humulus, Staphylococcus,
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Biofilms drug effects MeSH
- Cell Line MeSH
- Cyclohexenes pharmacology MeSH
- Flavonoids pharmacology MeSH
- Humulus chemistry MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Propiophenones pharmacology MeSH
- Plant Extracts pharmacology MeSH
- Staphylococcus drug effects genetics growth & development MeSH
- Terpenes pharmacology MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Cyclohexenes MeSH
- Flavonoids MeSH
- humulon MeSH Browser
- lupulon MeSH Browser
- Propiophenones MeSH
- Plant Extracts MeSH
- Terpenes MeSH
- xanthohumol MeSH Browser
Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials, and staphylococci are recognized as the most frequent cause of biofilm-associated infections. The hop plant (Humulus lupulus L.) contains substances that have been determined to act as anti-infective agents against bacteria, mainly in planktonic form. Therefore, we decided to investigate the antibiofilm properties of H. lupulus L.-derived compounds (humulone, lupulone and xanthohumol) against a selected group of Staphylococcus spp., including methicillin-susceptible and resistant strains. All tested hop compounds were shown to possess antimicrobial properties against all tested staphylococci, both planktonic and biofilm-dwelling, with no significant difference between resistant and susceptible strains. All compounds lowered the number of bacterial cells released from the biofilm, with the strongest effect seen for lupulone, followed by xanthohumol. Moreover, lupulone and xanthohumol were not only able to penetrate the biofilm and reduce the number of bacteria within it, but their higher concentrations (∼60 μg/mL for xanthohumol and ∼125 μg/mL for lupulone) reduced the number of surviving bacterial cells to zero.
References provided by Crossref.org
Prenylated Flavonoids in Topical Infections and Wound Healing
