A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution
Chemistry (Weinheim an der Bergstrasse, Germany).
2018 Apr 03 ;
24 (19) :
4957-4966.
[epub] 20180312
Language English Country Germany Media print-electronic
Document type Journal Article
Persistent link
https://www.medvik.cz/link/pmid29411907
- Keywords
- cytotoxicity, dyes/pigments, fluorescence microscopy, solid-phase synthesis, terpenoids,
- MeSH
- Biological Transport MeSH
- Microscopy, Fluorescence MeSH
- Humans MeSH
- Boron Compounds chemical synthesis chemistry MeSH
- Tissue Distribution physiology MeSH
- Triterpenes analysis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene MeSH Browser
- Boron Compounds MeSH
- Triterpenes MeSH
A solid-phase synthetic (SPS) method was developed for the preparation of BODIPY-labeled bioactive compounds that allows for fast and simple synthesis of conjugates for use in fluorescent microscopy. The approach was used to visualize cellular uptake and distribution of cytotoxic triterpenes in cancer cells.
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