Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
Grantová podpora
DRF-2014-07-088
Department of Health - United Kingdom
PubMed
29516396
DOI
10.1007/s11695-018-3180-5
PII: 10.1007/s11695-018-3180-5
Knihovny.cz E-zdroje
- Klíčová slova
- Acetone, Bariatric surgery, Exhaled breath, Ketones, Low calorie diet, Nutrition, Obesity,
- MeSH
- aceton * analýza MeSH
- bariatrická chirurgie MeSH
- biologické markery MeSH
- dechové testy MeSH
- dieta MeSH
- dospělí MeSH
- gastrektomie * metody MeSH
- hmotnostní úbytek MeSH
- ketony * analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- morbidní obezita * chirurgie MeSH
- nutriční stav MeSH
- obezita chirurgie MeSH
- prospektivní studie MeSH
- průřezové studie MeSH
- žaludeční bypass * metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- aceton * MeSH
- biologické markery MeSH
- ketony * MeSH
BACKGROUND: Dietary restriction together with alteration of the gastrointestinal tract results in major metabolic changes and significant weight loss in patients undergoing bariatric surgery. Current methods of measuring these changes are often inaccurate and lack a molecular basis. The objective of this study was to determine the role of exhaled ketones as non-invasive markers of nutritional status in patients undergoing surgical treatment of obesity. METHODS: Patients at different stages of treatment for obesity were recruited to this single-centre cross-sectional study. The sample time points were as follows: (i) at the time of initial attendance prior to dietary or surgical interventions, (ii) on the day of surgery following a low carbohydrate diet, and (iii) > 3 months after either Roux-en-Y gastric bypass or sleeve gastrectomy. The concentrations of ketones within breath samples were analysed by selected ion flow tube mass spectrometry. RESULTS: Forty patients were recruited into each of the three study groups. Exhaled acetone concentrations increased significantly following pre-operative diet (1396 ppb) and bariatric surgery (1693 ppb) compared to the start of treatment (410 ppb, P < 0.0001). In comparison, concentrations of heptanone (6.5 vs. 4.1 vs. 1.4 ppb, P = 0.021) and octanone (3.0 vs. 1.4 vs. 0.7 ppb, P = 0.021) decreased significantly after dieting and surgical intervention. Exhaled acetone (ρ - 0.264, P = 0.005) and octanone (ρ 0.215, P = 0.022) concentrations were observed to correlate with excess body weight at the time of sampling. Acetone and octanone also correlated with neutrophil and triglyceride levels (P < 0.05). CONCLUSION: Findings confirm breath ketones, particularly acetone, to be a potentially clinically useful method of non-invasive nutritional assessment in obese patients.
Department of Surgery and Cancer Imperial College London St Marys Hospital London UK
J Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences Prague Czech Republic
Research Institute for Science and Technology in Medicine University of Keele Keele UK
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