Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017
Language English Country Austria Media print-electronic
Document type Journal Article
PubMed
29623433
DOI
10.1007/s00705-018-3833-7
PII: 10.1007/s00705-018-3833-7
Knihovny.cz E-resources
- MeSH
- Disease Outbreaks MeSH
- Phylogeny MeSH
- Genetic Variation MeSH
- Hemagglutinin Glycoproteins, Influenza Virus genetics MeSH
- Evolution, Molecular * MeSH
- Influenza in Birds epidemiology virology MeSH
- Birds classification virology MeSH
- Virulence MeSH
- Influenza A Virus, H5N8 Subtype classification genetics isolation & purification pathogenicity MeSH
- Influenza A virus classification genetics isolation & purification pathogenicity MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- hemagglutinin, avian influenza A virus MeSH Browser
- Hemagglutinin Glycoproteins, Influenza Virus MeSH
Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
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