Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
29789140
DOI
10.1016/j.jneuroim.2018.05.004
PII: S0165-5728(17)30594-5
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, Antibody, Mild cognitive impairment, Post-translational modification, Sex, Tau protein,
- MeSH
- Alzheimer Disease blood cerebrospinal fluid immunology MeSH
- Autoantibodies analysis blood cerebrospinal fluid MeSH
- Dementia blood cerebrospinal fluid immunology MeSH
- Species Specificity MeSH
- Phosphoproteins chemistry immunology MeSH
- Phosphorylation MeSH
- Cognitive Dysfunction blood cerebrospinal fluid immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Sex Characteristics * MeSH
- Protein Processing, Post-Translational MeSH
- tau Proteins chemistry immunology MeSH
- Recombinant Proteins immunology MeSH
- Reproducibility of Results MeSH
- Aged MeSH
- Cattle MeSH
- Antibody Specificity MeSH
- Animals MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Cattle MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Autoantibodies MeSH
- Phosphoproteins MeSH
- MAPT protein, human MeSH Browser
- tau Proteins MeSH
- Recombinant Proteins MeSH
The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies towards phosphorylated bovine tau protein than to human recombinant (non-phosphorylated) tau protein. Males with MCI-AD had higher amounts of these antibodies than corresponding controls. Concentrations of antibodies were lower in females with the MCI-AD than in control females. These findings may have implications for tau vaccination trials.
References provided by Crossref.org
Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases
