Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
15-31627A
Czech Health Research Council project
Ministry of Health of the Czech Republic
PubMed
30079604
DOI
10.1111/jop.12772
Knihovny.cz E-zdroje
- Klíčová slova
- EGFR, OPSCC, CD44, combined immunoprofiles, p16,
- MeSH
- antigeny CD44 analýza MeSH
- dospělí MeSH
- erbB receptory analýza MeSH
- imunohistochemie * MeSH
- inhibitor p16 cyklin-dependentní kinasy analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery analýza MeSH
- nádory orofaryngu diagnóza patologie MeSH
- prognóza MeSH
- senioři MeSH
- spinocelulární karcinom diagnóza patologie MeSH
- staging nádorů metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny CD44 MeSH
- CD44 protein, human MeSH Prohlížeč
- CDKN2A protein, human MeSH Prohlížeč
- EGFR protein, human MeSH Prohlížeč
- erbB receptory MeSH
- inhibitor p16 cyklin-dependentní kinasy MeSH
- nádorové biomarkery MeSH
OBJECTIVES: To examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on Cancer (AJCC) 8th edition staging system in comparison with 7th edition was analyzed. METHODS: The study included 77 OPSCC patients treated by definitive intensity-modulated radiotherapy (IMRT). Clinical staging was assessed according to the AJCC, both 7th and 8th edition. Immunohistochemical (IHC) analysis of CD44 and EGFR was performed on primary biopsy tumor tissues. To evaluate the HPV status, IHC detection of p16 was employed. RESULTS: The AJCC 8th edition staging system revealed correlations between overall survival (OS), progression-free survival (PFS), locoregional control (LRC), and clinical stage. EGFR and CD44 positivity (+) and p16 negativity (-) were associated with clinical stage IV of the disease. CD44+ and EGFR+ OPSCC displayed worse OS and LRC, and these cases also showed the worst 3-year OS and LRC. Combined analysis of protein expressions identified an association between p16- and EGFR+, p16- and CD44+, EGFR+, and CD44+. Combined immunoprofiles CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ were associated with worst OS and LRC. CONCLUSIONS: Combined immunoprofiles of p16, EGFR, and CD44 might provide valuable prognostic and predictive information for the individual OPSCC patients, especially in terms of response to IMRT and prediction of treatment outcomes. Application of the AJCC 8th edition staging for HPV+ OPSCC proved to improve hazard discrimination and prognostication of OPSCC.
Central European Institute of Technology Masaryk University Brno Czech Republic
Department of Comprehensive Cancer Care Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Mathematics and Statistics Faculty of Science Masaryk University Brno Czech Republic
Department of Physiology Medical Faculty Masaryk University Brno Czech Republic
Regional Centre for Applied Molecular Oncology Masaryk Memorial Cancer Institute Brno Czech Republic
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