Olfaction is an important sensory input that obviously affects many daily activities. However, olfactory dysfunction (hyposmia and anosmia) leads to a pronounced decrease in quality of life. Surprisingly, little attention has been paid to olfactory changes after transsphenoidal surgery for pituitary tumors. In this review, we summarize current knowledge of the effects of transsphenoidal pituitary surgery on olfaction and compare different surgical techniques. Based on selected studies, the endoscopic approach, in comparison with the microscopic approach, seems to be superior in terms of preservation of olfactory function, although the quality of data from these studies is generally poor. The best results were observed when the endoscopic approach was used without harvesting of the nasoseptal flap.

Department of Neurosurgery and Neurooncology 1st Faculty of Medicine Charles University and Military University Hospital U Vojenske nemocnice 1200 169 02 Prague Czech Republic

Department of Otorhinolaryngology and Maxillofacial Surgery 3rd Faculty of Medicine Charles University and Military University Hospital Prague Czech Republic

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Am J Rhinol. 1999 Jan-Feb;13(1):45-8 PubMed

Chem Senses. 2003 Oct;28(8):691-4 PubMed

Laryngoscope. 2006 Oct;116(10):1882-6 PubMed

PLoS Med. 2009 Jul 21;6(7):e1000097 PubMed

Otolaryngol Head Neck Surg. 2010 Jan;142(1):95-7 PubMed

Neurosurg Focus. 2010 Oct;29(4):E10 PubMed

Laryngoscope. 2011 May;121(5):990-3 PubMed

Laryngoscope. 2011 Aug;121(8):1611-3 PubMed

Am J Rhinol Allergy. 2011 Mar-Apr;25(2):125-7 PubMed

Int Forum Allergy Rhinol. 2013 Jan;3(1):62-5 PubMed

Int Forum Allergy Rhinol. 2013 Mar;3(3):217-20 PubMed

Neurosurgery. 2013 Apr;72(4):540-6 PubMed

Laryngoscope. 2013 Jul;123(7):1602-6 PubMed

Acta Med Port. 2013 May-Jun;26(3):200-7 PubMed

Laryngoscope. 2013 Sep;123(9):2112-9 PubMed

Chem Senses. 2014 Mar;39(3):185-94 PubMed

Laryngoscope. 2014 Nov;124(11):2470-5 PubMed

Acta Neurochir (Wien). 2014 Jul;156(7):1393-401 PubMed

Am J Rhinol Allergy. 2014 Nov-Dec;28(6):517-9 PubMed

Medicine (Baltimore). 2015 Jan;94(4):e465 PubMed

Am J Rhinol Allergy. 2015 Mar-Apr;29(2):145-50 PubMed

Am J Rhinol Allergy. 2015 May-Jun;29(3):221-5 PubMed

Otolaryngol Clin North Am. 2015 Oct;48(5):795-804 PubMed

Am J Rhinol Allergy. 2015 Sep-Oct;29(5):365-8 PubMed

J Neurol Surg B Skull Base. 2015 Dec;76(6):464-70 PubMed

World Neurosurg. 2016 Mar;87:162-9 PubMed

PLoS One. 2016 Mar 24;11(3):e0151531 PubMed

Laryngoscope. 2017 Sep;127(9):1970-1975 PubMed

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Laryngoscope Investig Otolaryngol. 2017 May 28;2(5):281-287 PubMed

J Neurosurg. 1987 Jan;66(1):140-2 PubMed

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